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Literature summary for 3.1.3.4 extracted from

  • Carman, G.M.; Wu, W.I.
    Lipid phosphate phosphatases from Saccharomyces cerevisiae (2007), Methods Enzymol., 434, 305-315.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Spodoptera frugiperda Sf9 cells using the baculovirus expression system, and in Saccharomyces cerevisiae using multicopy plasmids Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
diacylglycerol diphosphate
-
Saccharomyces cerevisiae
NEM
-
Saccharomyces cerevisiae
phosphatidic acid substrate inhibition Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane lipid phosphate phosphatase enzymes possess a three-domain lipid phosphatase motif that is localized to the hydrophilic surface of the membrane Saccharomyces cerevisiae 16020
-
microsome
-
Saccharomyces cerevisiae
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidic acid + H2O Saccharomyces cerevisiae lipid phosphate phosphatase enzymes may play a role in signal transduction by terminating signaling events of lipid phosphates 1,2-diacylglycerol + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
gene llp1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme also shows diacylglycerol lipase activity, EC 3.1.1.34, overview Saccharomyces cerevisiae ?
-
?
phosphatidic acid + H2O lipid phosphate phosphatase enzymes may play a role in signal transduction by terminating signaling events of lipid phosphates Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate
-
?
phosphatidic acid + H2O the conserved arginine residue in domain 1 and the conserved histidine residues in domains 2 and 3 are essential for catalytic activity Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate
-
?

Subunits

Subunits Comment Organism
More lipid phosphate phosphatase enzymes possess a three-domain lipid phosphatase motif that is localized to the hydrophilic surface of the membrane, the conserved arginine residue in domain 1 and the conserved histidine residues in domains 2 and 3 are essential for catalytic activity Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase
-
Saccharomyces cerevisiae
LLP1
-
Saccharomyces cerevisiae
More cf. EC 3.1.1.34 Saccharomyces cerevisiae
PA phosphatase
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Saccharomyces cerevisiae