Literature summary for 3.1.3.4 extracted from

Pilquil, C.; Dewald, J.; Cherney, A.; Gorshkova, I.; Tigyi, G.; English, D.; Natarajan, V.; Brindley, D.N.
Lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation (2006), J. Biol. Chem., 281, 38418-38429.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	increasing the catalytic activity of LPP1 decreases the pertussis toxin-sensitive stimulation of fibroblast migration by lyso-phosphatidic acid and an lyso-phosphatidic acid-receptor agonist, that can not be dephosphorylated	Rattus norvegicus

Application

Application	Comment	Organism
medicine	LPP1 overexpressing fibroblasts show a severe inhibition of lyso-phosphatidic acid-induced migration in a wound healing assay. Intracellular actions of LPP1 play important functions in regulating lyso-phosphatidic acid-induced fibroblast migration through phospholipase D2, also controls platelet-derived growth factor-betabeta-induced phosphatidate formation	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
gene Lpp1, stable overexpression of wild-type and mutant LPP1 enzymes in Rat2 fibroblasts using a retroviral vector and puromycin selection	Mus musculus
rat2 fibroblasts infected with adenoviral vectors containing LPP1-myc or LPP1(R217K)-myc. Rat2 fibroblasts stably overexpressing LPP1	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	LPP1 overexpressing fibroblasts show a severe inhibition of LPA-induced migration not mediated through the degradation of extracellular LPA in a woundhealing assay, overview	Mus musculus
R217K	site-directed mutagenesis, inactive mutant	Mus musculus
R217K	inactive, mutant shows no decrease of lyso-phosphatidic acid-induced fibroblast migration	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
siRNA	decrease of LPP1 mRNA by ca. 90%, knockdown of endogenous LPP1 activity by about 50% and increase of lyso-phosphatidic acid-induced migration	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphatidic acid + H2O	Mus musculus	lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation, LPP1 expression decreases PLD activity and PA accumulation after stimulating fibroblasts with either LPA or PDGF, but PLD-dependent PA formation Is only required for LPA-induced fibroblast migration, overview	1,2-diacylglycerol + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,2-dioleoyl-sn-glycerol-3 phosphate	-	Mus musculus	1,2-dioleoyl-sn-glycerol + phosphate	-	?
lyso-phosphatidic acid + H2O	-	Rattus norvegicus	monoacylglycerol + phosphate	-	?
phosphatidic acid + H2O	lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation, LPP1 expression decreases PLD activity and PA accumulation after stimulating fibroblasts with either LPA or PDGF, but PLD-dependent PA formation Is only required for LPA-induced fibroblast migration, overview	Mus musculus	1,2-diacylglycerol + phosphate	-	?
phosphatidic acid + H2O	-	Rattus norvegicus	diacylglycerol + phosphate	-	?
sphingosine 1-phosphate + H2O	-	Rattus norvegicus	sphingosine + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
lipid phosphate phosphatase-1	-	Mus musculus
lipid phosphate phosphatase-1	-	Rattus norvegicus
LPP1	-	Mus musculus
LPP1	-	Rattus norvegicus

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Release 2023.1 (January 2023)