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Literature summary for 3.1.3.4 extracted from

  • Takeuchi, M.; Harigai, M.; Momohara, S.; Ball, E.; Abe, J.; Furuichi, K.; Kamatani, N.
    Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase (2007), Gene, 399, 174-180.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozyme DPPL1 in Spodoptera frugiperda Sf9 cells Homo sapiens
expression of isozyme DPPL2 in Spodoptera frugiperda Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
NEM inhibition of isozyme DPPL1; inhibition of isozyme DPPL2 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.041
-
diacylglycerol diphosphate pH 6.5, 37°C, recombinant isozyme DPPL1 Homo sapiens
0.104
-
diacylglycerol diphosphate pH 6.5, 37°C, recombinant isozyme DPPL2 Homo sapiens
0.277
-
phosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL1 Homo sapiens
0.295
-
lysophosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL1 Homo sapiens
0.506
-
phosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL2 Homo sapiens
0.58
-
lysophosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL2 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information isozyme DPPL1 is Mg2+-independent Homo sapiens
additional information isozyme DPPL2 is Mg2+-independent Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VZY2 DPPL2; isozyme DPPL2
-
Homo sapiens Q8NEB5 DPPL1; isozyme DPPL1
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
blood vessel synovium containing, specific expression of DPPL2 Homo sapiens
-
brain isozyme DPPL2 Homo sapiens
-
endothelial cell isozyme DPPL2 Homo sapiens
-
endothelium specific expression of DPPL2, expression in endothelial cell lines, overview Homo sapiens
-
IM-9 cell
-
Homo sapiens
-
JURKAT cell
-
Homo sapiens
-
kidney isozyme DPPL2 Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
additional information DPPL1 is ubiquitously expressed in various tissues and cells, overview Homo sapiens
-
additional information DPPL2 mRNA is restricted to several tissues, expression in cancer cell lines, overview Homo sapiens
-
PC-3 cell
-
Homo sapiens
-
plasma cell specific expression of DPPL2 Homo sapiens
-
T-lymphocyte specific expression of DPPL2 Homo sapiens
-
testis isozyme DPPL2 Homo sapiens
-
THP-1 cell
-
Homo sapiens
-
WiDr cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL1 Homo sapiens ?
-
?
diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL2 Homo sapiens ?
-
?
lysophosphatidic acid + H2O
-
Homo sapiens ?
-
?
phosphatidic acid + H2O
-
Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
?

Synonyms

Synonyms Comment Organism
DPPL1
-
Homo sapiens
DPPL2
-
Homo sapiens
More cf. EC 3.1.3.B2 Homo sapiens
PAP
-
Homo sapiens
phosphatidate phosphatase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Homo sapiens