Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzymes in rat2 fibroblasts | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G170A | 38% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
H171L | 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
H223L | 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
I233T | 94% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
K120R | 5% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
L106S | 85% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
N142Q | 89% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate, mutation decreases the molecular weight by about 4000 Da | Mus musculus |
N276Q | 112% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
P128I | 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
R127K | 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
R217K | 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
S169T | 0.4% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
T116I | 91% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
T122S | 97% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
T5P | 85% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
Y168F | 87% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
Y221W | 51% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | active site located on the outer surface | Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | glycosylation is not required for activity | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase-1 | - |
Mus musculus |
LPP-1 | - |
Mus musculus |