Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.4 extracted from

  • Zhang, Q.X.; Pilquil, C.S.; Dewald, J.; Berthiaume, L.G.; Brindley, D.N.
    Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action (2000), Biochem. J., 345, 181-184.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in rat2 fibroblasts Mus musculus

Protein Variants

Protein Variants Comment Organism
G170A 38% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
H171L 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
H223L 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
I233T 94% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
K120R 5% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
L106S 85% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
N142Q 89% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate, mutation decreases the molecular weight by about 4000 Da Mus musculus
N276Q 112% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
P128I 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
R127K 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
R217K 2% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
S169T 0.4% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
T116I 91% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
T122S 97% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
T5P 85% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
Y168F 87% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus
Y221W 51% of the dephosphorylation activity of the wild-type enzyme with lysophosphatidate as substrate Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane active site located on the outer surface Mus musculus 5886
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein glycosylation is not required for activity Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidic acid + H2O
-
Mus musculus monoacylglycerol + phosphate
-
?

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase-1
-
Mus musculus
LPP-1
-
Mus musculus