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Literature summary for 3.1.3.4 extracted from
- Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes (1992), J. Biol. Chem., 267, 25309-25314.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | Triton X-100 or deoxycholate required | Sus scrofa |  |
| Triton X-100 | Triton X-100 or deoxycholate required | Sus scrofa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,2-diacylglycerol | - |
Sus scrofa | |
| Ca2+ | - |
Sus scrofa | |
| chlorpromazine | - |
Sus scrofa | |
| F- | NaF | Sus scrofa | |
| Mn2+ | - |
Sus scrofa | |
| NEM | no inhibition | Sus scrofa | |
| propanolol | - |
Sus scrofa | |
| sphingosine | - |
Sus scrofa | |
| Zn2+ | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| integral to plasma membrane | - |
Sus scrofa | - |
- |
| plasma membrane | - |
Sus scrofa | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | independent of Mg2+ | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 83000 | - |
x * 83000, SDS-PAGE under reducing and nonreducing conditions | Sus scrofa |
| 218000 | - |
gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymus | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 15.8 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lysophosphatidate + H2O | poor substrate | Sus scrofa | ? | - |
? | |
| phosphatidic acid + H2O | - |
Sus scrofa | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 83000, SDS-PAGE under reducing and nonreducing conditions | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.4 | - |
Sus scrofa |
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