Literature summary for 3.1.3.4 extracted from

Yeung, A.; Casola, P.G.; Wong, C.; Fellows, J.F.; Possmayer, F.
Pulmonary phosphatidic acid phosphatase. A comparative study of the aqueously dispersed phosphatidate-dependent and membrane-bound phosphatidate-dependent phosphatidic acid phosphatase activities of rat lung (1979), Biochim. Biophys. Acta, 574, 226-239.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Ca2+	activity with aqueously dispersed phosphatidic acid	Rattus norvegicus
F-	activity with aqueously dispersed phosphatidic acid	Rattus norvegicus
Mg2+	at high concentrations, activity with aqueously dispersed phosphatidic acid	Rattus norvegicus
Mn2+	activity with aqueously dispersed phosphatidic acid	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidic acid + H2O	-	Rattus norvegicus	1,2-diacyl-sn-glycerol + phosphate	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6	6.5	and the major activity peak at pH 7.5-8.0, aqueously dispersed phosphatidic acid, cytosolic activity	Rattus norvegicus
6.5	-	and a minor peak of activity at pH 7.5-8, aqueously dispersed phosphatidic acid, microsomal enzyme	Rattus norvegicus
6.5	7.5	membrane-bound phosphatidic acid, microsomal enzyme	Rattus norvegicus
7.4	8	membrane-bound phosphatidic acid, cytosolic enzyme	Rattus norvegicus
7.5	8	and a distinct optimum at pH 6.0-6.5, aqueously dispersed phosphatidic acid, cytosolic enzyme	Rattus norvegicus

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Release 2023.1 (January 2023)