Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Caenorhabditis elegans | 5768 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Caenorhabditis elegans | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Caenorhabditis elegans | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 96000, GST-tagged enzyme, SDS-PAGE | Caenorhabditis elegans |
Synonyms | Comment | Organism |
---|---|---|
phosphoinositide phosphatase | - |
Caenorhabditis elegans |
SAC-1 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme depletion exclusively impairs apical secretory transport in intestinal epithelia. Enzyme loss leads to increased phosphatidylinositol 4,5-bisphosphate levels and overaccumulation of actin structures as well as intracellular accumulation of ARF-6 and UNC-16 | Caenorhabditis elegans |
metabolism | the interaction of the enzyme with ARF-6 curbs ARF-6 activity by limiting the access of ARF-6(GDP) to its guanine nucleotide exchange factor, BRIS-1 | Caenorhabditis elegans |