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Literature summary for 3.1.3.36 extracted from

  • Dambournet, D.; MacHicoane, M.; Chesneau, L.; Sachse, M.; Rocancourt, M.; El Marjou, A.; Formstecher, E.; Salomon, R.; Goud, B.; Echard, A.
    Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis (2011), Nat. Cell Biol., 13, 981-988.
    View publication on PubMed
Search for more literature for 3.1.3.36

Protein Variants

Protein Variants Comment Organism
additional information downregulation of the enzyme in HeLa cells by RNAi Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens preferred substrate 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Homo sapiens 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
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 ?

Synonyms

Synonyms Comment Organism
OCRL phosphatase
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 Homo sapiens
phosphatidylinositol-4,5-bisphosphate 5-phosphatase
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 Homo sapiens
PtdIns(4;5)P2 5-phosphatase
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 Homo sapiens

General Information

General Information Comment Organism
malfunction the phosphatidylinositol-4,5-bisphosphate 5-phosphatase OCRL is mutated in Lowe syndrome patients. Depletion of Rab35 or OCRL inhibits cytokinesis abscission and is associated with local abnormal PtdIns(4;5)P2 and F-actin accumulation in the intercellular bridge, pleiotropic phenotypes associated with Lowe disease, overview Homo sapiens
additional information GTP-bound, active Rab35 directly interacts with OCRL and controls its localization at the intercellular bridge Homo sapiens
physiological function the phosphatidylinositol-4,5-bisphosphate 5-phosphatase OCRL is a downstream effector of the Rab35 GTPase in cytokinesis abscission. PtdIns(4;5)P2 hydrolysis is important for normal cytokinesis abscission to locally remodel the F-actin cytoskeleton in the intercellular bridge, role for the phosphatase OCRL in cell division Homo sapiens