Literature summary for 3.1.3.36 extracted from

Fabian, L.; Wei, H.; Rollins, J.; Noguchi, T.; Blankenship, J.; Bellamkonda, K.; Polevoy, G.; Gervais, L.; Guichet, A.; Fuller, M.; Brill, J.
Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila (2010), Mol. Biol. Cell, 21, 1546-1555.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Drosophila melanogaster	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	Drosophila melanogaster	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is required for formation, polarization, and elongation of spermatid cysts, overview	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatid	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Drosophila melanogaster	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is required for formation, polarization, and elongation of spermatid cysts, overview	Drosophila melanogaster	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PIP2 phosphatase	-	Drosophila melanogaster
SigD	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
malfunction	reduction of plasma membrane phosphatidylinositol 4,5-bisphosphate by low-level expression of the PIP2 phosphatase SigD or mutation of the PIP2 biosynthetic enzyme Skittles results in dramatic defects in spermatid cysts, which become bipolar and fail to fully elongate	Drosophila melanogaster

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Release 2023.1 (January 2023)