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Literature summary for 3.1.3.36 extracted from

  • Ben El Kadhi, K.; Roubinet, C.; Solinet, S.; Emery, G.; Carreno, S.
    The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis (2011), Curr. Biol., 21, 1074-1079.
    View publication on PubMed
Search for more literature for 3.1.3.36

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome dOCRL is associated with endosomes Drosophila melanogaster 5768
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membrane dOCRL dephosphorylates PI(4,5)P2 on internal membranes Drosophila melanogaster 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Drosophila melanogaster
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 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Drosophila melanogaster 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dOCRL orthologue of the human oculocerebrorenal syndrome of Lowe 1, i.e. OCRL1 Drosophila melanogaster
inositol 5-phosphatase
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction in absence of dOCRL, several essential components of the cleavage furrow are found to be incorrectly localized on giant cytoplasmic vacuoles rich in PI(4,5)P2 and in endocytic markers Drosophila melanogaster
physiological function dOCRL is essential for cytokinesis and cell division, it dephosphorylates phosphatidylinositol-4,5-bisphosphate on internal membranes to restrict this phosphoinositide at the plasma membrane and thereby regulates cleavage furrow formation and ingression. dOCRL is required for proper furrowing of the contractile ring and proper assembly Drosophila melanogaster