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Literature summary for 3.1.3.36 extracted from

  • Zhang, Y.; Wavreille, A.S.; Kunys, A.R.; Pei, D.
    The SH2 domains of inositol polyphosphate 5-phosphatases SHIP1 and SHIP2 have similar ligand specificity but different binding kinetics (2009), Biochemistry, 48, 11075-11083.
    View publication on PubMed
Search for more literature for 3.1.3.36

Cloned(Commentary)

Cloned (Comment) Organism
SH2 domain Homo sapiens
SH2 domain, a maltose-binding protein fusion protein and a His-tagged version expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
P105E Glu in SHIP1 SH2 domain, faster association kinetics for binding to immobilized peptide VApYSYL Homo sapiens
P88S Ser in SHIP1 SH2 domain, faster association kinetics for binding to immobilized peptide VApYSYL Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized metal ion affinity chromatography (Co2+), gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol polyphosphate 5-phosphatase
-
 Homo sapiens
SHIP1
-
 Homo sapiens
SHIP2
-
 Homo sapiens