Literature summary for 3.1.3.36 extracted from

Thyagarajan, B.; Lukacs, V.; Rohacs, T.
Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels (2008), J. Biol. Chem., 283, 14980-14987.

Search for more literature for 3.1.3.36

Application

Application	Comment	Organism
molecular biology	hydrolysis of phosphatidylinositol 4,5-bisphosphate by PI(4,5)P2 5-phosphatase mediates calcium-induced inactivation of TRPV6 channels	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK293 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	a rapamycin-inducible PI(4,5)P2 5-phosphatase is used to deplete PI(4,5)P2 in TRPV6-expressing cells. This technique is based on the translocation of the phosphatase domain of the PI(4,5)P2 5-phosphatase to the plasma membrane induced by rapamycin, which is shown to cause depletion of PI(4,5)P2. Rapamycin (100 nM) inhibits the whole-cell monovalent currents through TRPV6 channels expressing the rapamycin-inducible PI(4,5)P2 5-phosphatase constructs and has no effect in parallel controls	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylinositol 4,5-bisphosphate + H2O	-	Homo sapiens	phosphatidylinositol 4-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
rapamycin-inducible PI(4,5)P2 5-phosphatase	-	Homo sapiens

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Release 2023.1 (January 2023)