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Literature summary for 3.1.3.36 extracted from

  • Schmid, A.C.; Wise, H.M.; Mitchell, C.A.; Nussbaum, R.; Woscholski, R.
    Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation (2004), FEBS Lett., 576, 9-13.
    View publication on PubMed
Search for more literature for 3.1.3.36

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged catalytic domain comprising residues A305-A721, in Escherichia coli strain DH5alpha Mus musculus
expression of GST-tagged catalytic domain comprising residues S470-R962, in Escherichia coli strain DH5alpha Rattus norvegicus
expression of GST-tagged catalytic domains, comprising residues D474-R959 of synaptojanin2 and residues V202-E618 of OCRL, in Escherichia coli strain DH5alpha Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GST-tagged catalytic domains from Escherichia coli strain DH5alpha by glutathione affinity chromatography Mus musculus
recombinant GST-tagged catalytic domains from Escherichia coli strain DH5alpha by glutathione affinity chromatography Rattus norvegicus
recombinant GST-tagged catalytic domains of synaptojanin2 and OCRL from Escherichia coli strain DH5alpha by glutathione affinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O good substrate Rattus norvegicus 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O best substrate for OCRL Homo sapiens 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Mus musculus 1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Rattus norvegicus 1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O good substrate of OCRL, not synaptojanin2 Homo sapiens 1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
1D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Mus musculus 1D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
1D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O 3-O-phospho-linked Homo sapiens D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O 3-O-phospho-linked Rattus norvegicus D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O 3-O-phospho-linked, best substrate Mus musculus D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 3-O-phospho-linked, best substrate Mus musculus D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 3-O-phospho-linked, best substrate for synaptojanin1 Rattus norvegicus D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 3-O-phospho-linked, best substrate for synaptojanin2 Homo sapiens D(+)-sn-1,2-di-O-hexadecanoylglyceryl 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
additional information substrate specificity, no activity with 1D-myo-inositol 1,5-bisphosphate and 1D-myo-inositol 1,4,5-trisphosphate, overview Rattus norvegicus ?
-
 ?
additional information substrate specificity, no activity with 1D-myo-inositol 1,5-bisphosphate, overview Mus musculus ?
-
 ?
additional information substrate specificity, no activity with 1D-myo-inositol 1,5-bisphosphate, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
INPP5B
-
 Mus musculus
More cf. EC 3.1.3.56, inositol polyphosphate 5-phosphatase Mus musculus
More cf. EC 3.1.3.56, inositol polyphosphate 5-phosphatase Homo sapiens
More cf. EC 3.1.3.56, inositol polyphosphate 5-phosphatase Rattus norvegicus
OCRL
-
 Homo sapiens
synaptojanin1
-
 Rattus norvegicus
synaptojanin2
-
 Homo sapiens
type II phosphoinositide 5-phosphatase
-
 Mus musculus
type II phosphoinositide 5-phosphatase
-
 Homo sapiens
type II phosphoinositide 5-phosphatase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus
30
-
 assay at Homo sapiens
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Homo sapiens
7.4
-
 assay at Rattus norvegicus