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Literature summary for 3.1.3.34 extracted from
- Deoxyribonucleotide phosphatase from rat liver and cultured mouse fibroblasts (1971), Eur. J. Biochem., 20, 225-230.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dGMP | competitive to dTMP dephosphorylation | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.7 | - |
deoxythymidine 5'-phosphate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for maximal activity | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside 3'-phosphate + H2O | Mus musculus | - |
deoxynucleoside + phosphate | - |
? | |
| deoxynucleoside 3'-phosphate + H2O | Rattus norvegicus | - |
deoxynucleoside + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, pH 8.0, 2 mM dithiothreitol, at least 1 week without loss of activity | Rattus norvegicus |
| liquid N2, as precipitate in 80% ammonium sulfate, 2 mM dithiothreitol, no inactivation after 1 year | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-dAMP + H2O | - |
Rattus norvegicus | 3'-deoxyadenosine + phosphate | - |
? | |
| 3'-dGMP + H2O | - |
Rattus norvegicus | deoxyguanosine + phosphate | - |
? | |
| deoxynucleoside 3'-phosphate + H2O | - |
Mus musculus | deoxynucleoside + phosphate | - |
? | |
| deoxynucleoside 3'-phosphate + H2O | - |
Rattus norvegicus | deoxynucleoside + phosphate | - |
? | |
| dTMP + H2O | - |
Mus musculus | thymidine + phosphate | - |
? | |
| dTMP + H2O | - |
Rattus norvegicus | thymidine + phosphate | - |
? | |
| thymidine 3'-monophosphate + H2O | - |
Rattus norvegicus | thymidine + phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 8 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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