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Literature summary for 3.1.3.32 extracted from

  • Freschauf, G.K.; Karimi-Busheri, F.; Ulaczyk-Lesanko, A.; Mereniuk, T.R.; Ahrens, A.; Koshy, J.M.; Rasouli-Nia, A.; Pasarj, P.; Holmes, C.F.; Rininsland, F.; Hall, D.G.; Weinfeld, M.
    Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase (2009), Cancer Res., 69, 7739-7746.
    View publication on PubMed
Search for more literature for 3.1.3.32

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus
-
 Homo sapiens
-
 Schizosaccharomyces pombe

Inhibitors

Inhibitors Comment Organism Structure
2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A12B4C3 Homo sapiens
2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A12B4C3 Mus musculus
2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A12B4C3 Schizosaccharomyces pombe
2-(hydroxy(3,4,5-trimethoxyphenyl)methyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A6B4C3 Homo sapiens
2-(hydroxy(phenyl)methyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A1B4C3 Homo sapiens
2-(hydroxy(thiophen-2-yl)methyl)-6-methyl-1-(phenylamino)-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione A39B1C2 Homo sapiens
tert-butyl 2-(1-hydroxy-2,2-diphenylethyl)-6-methyl-5,7-dioxo-2,4a,5,6,7,7a-hexahydro-1H-pyrrolo[3,4-b]pyridin-1-ylcarbamate A26B11C2 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57100
-
 x * 57100 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Schizosaccharomyces pombe
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus
-
 Homo sapiens
-
 Schizosaccharomyces pombe

Subunits

Subunits Comment Organism
? x * 57100 Homo sapiens

Synonyms

Synonyms Comment Organism
polynucleotide kinase/phosphatase
-
 Mus musculus
polynucleotide kinase/phosphatase
-
 Homo sapiens
polynucleotide kinase/phosphatase
-
 Schizosaccharomyces pombe

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 32% inhibition at 0.05 mM Schizosaccharomyces pombe 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione
additional information
-
 94% inhibition at 0.05 mM Mus musculus 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione
0.00006
-
 near maximal inhibition with 0.010 mM Homo sapiens 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione
0.0003
-
-
 Homo sapiens 2-(hydroxy(3,4,5-trimethoxyphenyl)methyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione