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Literature summary for 3.1.3.25 extracted from

  • Ferruz, N.; Tresadern, G.; Pineda-Lucena, A.; De Fabritiis, G.
    Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme (2016), Sci. Rep., 6, 30275 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ enzyme depends on 3 Mg2+ ions as cofactor for its catalytic activity. The first and second Mg2+ ions identify the binding pocket with fast kinetics whereas the third ion presents a much higher energy barrier. Substrate binding can occur in cooperation with cofactor, or alone to a binary or ternary cofactor-IMPase complex Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P29218
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