Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D460N | loss of activity with phosphatidylinositol 4-phosphate | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | colocalizes with 5-phosphatase OCRL on endocytic membranes including vesicles formed by clathrin-mediated endocytosis, macropinosomes, and Rab5 endosomes | Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8CDA1 | isoform INPP5f | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | selctive for phosphatidylinositol 4-phosphate, no reaction with other phosphatidylinositols tested | Mus musculus | ? | - |
? | |
phosphatidylinositol 4-phosphate + H2O | - |
Mus musculus | phosphatidylinositol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
INPP5f | - |
Mus musculus |
Sac2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | Sac2/INPP5F interacts with 5-phosphatase OCRL which is potentiated by Rab5. Rab5 activity is required to recruit Sac2/INPP5F to endosomes | Mus musculus |