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Literature summary for 3.1.3.25 extracted from

  • Zheng, W.; Brandish, P.E.; Kolodin, D.G.; Scolnick, E.M.; Strulovici, B.
    High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors (2004), J. Biomol. Screen., 9, 132-140.
    View publication on PubMed
Search for more literature for 3.1.3.25

Application

Application Comment Organism
drug development the enzyme is a target for development of lithium-mimetic agents for the treatment of bipolar disorder, high-throughput cell-based screening using scintillation proximity assay for the discovery of enzyme inhibitors, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-690330 bisphosphonate enzyme inhibitor Homo sapiens
L-690488 a tetrapivaloyloxymethyl ester prodrug of L-690330 Homo sapiens
Li+
-
 Homo sapiens
additional information high-throughput cell-based screening using scintillation proximity assay measuring G-protein-coupled receptor activation for evaluation of inhibitory potency of lithium mimetics, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in development of bipolar disorder ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 scintillation proximity assay development Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1-phosphate + H2O
-
 Homo sapiens D-myo-inositol + phosphate
-
 ?
additional information the enzyme is involved in development of bipolar disorder Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
IMPase
-
 Homo sapiens
inositol phosphatase
-
 Homo sapiens