BRENDA - Enzyme Database
show all sequences of 3.1.3.25

MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase

Stec, B.; Yang, H.; Johnson, K.A.; Chen, L.; Roberts, M.F.; Nat. Struct. Biol. 7, 1046-1050 (2000)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
-
Archaeoglobus fulgidus
-
Thermotoga maritima
expressed in Escherichia coli
Methanocaldococcus jannaschii
Crystallization (Commentary)
Crystallization
Organism
hanging drop vapour diffusion method, best crystals in the presence of Zn2+ and phosphate
Methanocaldococcus jannaschii
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.038
-
D-fructose 1,6-bisphosphate
85°C
Methanocaldococcus jannaschii
0.07
-
myo-inositol 1-phosphate
37°C
Escherichia coli
0.091
-
myo-inositol 1-phosphate
85°C
Methanocaldococcus jannaschii
0.11
-
myo-inositol 1-phosphate
85°C
Archaeoglobus fulgidus
0.13
-
myo-inositol 1-phosphate
95°C
Thermotoga maritima
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-fructose 1,6-bisphosphate + H2O
Methanocaldococcus jannaschii
very effective substrate
D-fructose 6-phosphate + phosphate
-
Methanocaldococcus jannaschii
?
D-fructose 1,6-bisphosphate + H2O
Archaeoglobus fulgidus
very effective substrate
D-fructose 6-phosphate + phosphate
-
Archaeoglobus fulgidus
?
D-fructose 1,6-bisphosphate + H2O
Thermotoga maritima
very effective substrate
D-fructose 6-phosphate + phosphate
-
Thermotoga maritima
?
D-fructose 1,6-bisphosphate + H2O
Thermotoga maritima TM1415
very effective substrate
D-fructose 6-phosphate + phosphate
-
Thermotoga maritima TM1415
?
D-fructose 1,6-bisphosphate + H2O
Archaeoglobus fulgidus AF2372
very effective substrate
D-fructose 6-phosphate + phosphate
-
Archaeoglobus fulgidus AF2372
?
myo-inositol 1-phosphate + H2O
Escherichia coli
-
myo-inositol + phosphate
-
Escherichia coli
?
myo-inositol 1-phosphate + H2O
Methanocaldococcus jannaschii
organism do not contain lipids with inositol head group, involved in the response to thermal stress
myo-inositol + phosphate
-
Methanocaldococcus jannaschii
?
myo-inositol 1-phosphate + H2O
Archaeoglobus fulgidus
organism do not contain lipids with inositol head group, involved in the response to thermal stress
myo-inositol + phosphate
-
Archaeoglobus fulgidus
?
myo-inositol 1-phosphate + H2O
Thermotoga maritima
organism do not contain lipids with inositol head group, involved in the response to thermal stress
myo-inositol + phosphate
-
Thermotoga maritima
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Archaeoglobus fulgidus
-
-
-
Archaeoglobus fulgidus AF2372
-
-
-
Escherichia coli
-
-
-
Methanocaldococcus jannaschii
Q57573
-
-
Thermotoga maritima
-
-
-
Thermotoga maritima TM1415
-
-
-
Purification (Commentary)
Commentary
Organism
-
Thermotoga maritima
-
Methanocaldococcus jannaschii
-
Archaeoglobus fulgidus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2'-AMP + H2O
600% of the rate with inositol 1-phosphate
653307
Methanocaldococcus jannaschii
adenosine + phosphate
-
653307
Methanocaldococcus jannaschii
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Methanocaldococcus jannaschii
4-nitrophenol + phosphate
-
653307
Methanocaldococcus jannaschii
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus
4-nitrophenol + phosphate
-
653307
Archaeoglobus fulgidus
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Thermotoga maritima
4-nitrophenol + phosphate
-
653307
Thermotoga maritima
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Thermotoga maritima TM1415
4-nitrophenol + phosphate
-
653307
Thermotoga maritima TM1415
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus AF2372
4-nitrophenol + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Methanocaldococcus jannaschii
alpha-D-glucose + phosphate
-
653307
Methanocaldococcus jannaschii
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus
alpha-D-glucose + phosphate
-
653307
Archaeoglobus fulgidus
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Thermotoga maritima
alpha-D-glucose + phosphate
-
653307
Thermotoga maritima
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Thermotoga maritima TM1415
alpha-D-glucose + phosphate
-
653307
Thermotoga maritima TM1415
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus AF2372
alpha-D-glucose + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Methanocaldococcus jannaschii
D-fructose 6-phosphate + phosphate
-
653307
Methanocaldococcus jannaschii
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus
D-fructose 6-phosphate + phosphate
-
653307
Archaeoglobus fulgidus
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Thermotoga maritima
D-fructose 6-phosphate + phosphate
-
653307
Thermotoga maritima
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Thermotoga maritima TM1415
D-fructose 6-phosphate + phosphate
-
653307
Thermotoga maritima TM1415
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus AF2372
D-fructose 6-phosphate + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
D-fructose 2,6-bisphosphate + H2O
16% of the rate with inositol 1-phosphate
653307
Methanocaldococcus jannaschii
D-fructose 6-phosphate + phosphate
-
653307
Methanocaldococcus jannaschii
?
glycerol 2-phosphate + H2O
-
653307
Methanocaldococcus jannaschii
glycerol + phosphate
-
653307
Methanocaldococcus jannaschii
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Archaeoglobus fulgidus
?
-
653307
Archaeoglobus fulgidus
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Thermotoga maritima
?
-
653307
Thermotoga maritima
?
additional information
D-glucose 6-phosphate, D-fructose 6-phosphate, 5'-AMP and NAD+ are not hydrolyzed
653307
Methanocaldococcus jannaschii
?
-
653307
Methanocaldococcus jannaschii
?
additional information
traces of activity with glucose 1-phosphate, no activity with 4-nitrophenyl phosphate and fructose 1,6-bisphosphate
653307
Escherichia coli
?
-
653307
Escherichia coli
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Thermotoga maritima TM1415
?
-
653307
Thermotoga maritima TM1415
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Archaeoglobus fulgidus AF2372
?
-
653307
Archaeoglobus fulgidus AF2372
?
myo-inositol 1-phosphate + H2O
-
653307
Escherichia coli
myo-inositol + phosphate
-
653307
Escherichia coli
?
myo-inositol 1-phosphate + H2O
-
653307
Methanocaldococcus jannaschii
myo-inositol + phosphate
-
653307
Methanocaldococcus jannaschii
?
myo-inositol 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus
myo-inositol + phosphate
-
653307
Archaeoglobus fulgidus
?
myo-inositol 1-phosphate + H2O
-
653307
Thermotoga maritima
myo-inositol + phosphate
-
653307
Thermotoga maritima
?
myo-inositol 1-phosphate + H2O
organism do not contain lipids with inositol head group, involved in the response to thermal stress
653307
Methanocaldococcus jannaschii
myo-inositol + phosphate
-
653307
Methanocaldococcus jannaschii
?
myo-inositol 1-phosphate + H2O
organism do not contain lipids with inositol head group, involved in the response to thermal stress
653307
Archaeoglobus fulgidus
myo-inositol + phosphate
-
653307
Archaeoglobus fulgidus
?
myo-inositol 1-phosphate + H2O
organism do not contain lipids with inositol head group, involved in the response to thermal stress
653307
Thermotoga maritima
myo-inositol + phosphate
-
653307
Thermotoga maritima
?
myo-inositol 1-phosphate + H2O
-
653307
Thermotoga maritima TM1415
myo-inositol + phosphate
-
653307
Thermotoga maritima TM1415
?
myo-inositol 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus AF2372
myo-inositol + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
myo-inositol 2-phosphate + H2O
15% of the rate with inositol 1-phosphate
653307
Methanocaldococcus jannaschii
myo-inositol + phosphate
-
653307
Methanocaldococcus jannaschii
?
Subunits
Subunits
Commentary
Organism
dimer
crystal structure analysis
Methanocaldococcus jannaschii
dimer
-
Archaeoglobus fulgidus
monomer
-
Escherichia coli
tetramer
-
Thermotoga maritima
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.5
-
myo-inositol 1-phosphate
50°C
Methanocaldococcus jannaschii
2.5
-
myo-inositol 1-phosphate
85°C
Archaeoglobus fulgidus
2.7
-
D-fructose 1,6-bisphosphate
85°C
Archaeoglobus fulgidus
2.7
-
D-fructose 1,6-bisphosphate
50°C
Methanocaldococcus jannaschii
4.2
-
myo-inositol 1-phosphate
85°C
Methanocaldococcus jannaschii
6.5
-
myo-inositol 1-phosphate
37°C
Escherichia coli
7
-
D-fructose 1,6-bisphosphate
85°C
Methanocaldococcus jannaschii
207
-
myo-inositol 1-phosphate
95°C
Thermotoga maritima
268
-
D-fructose 1,6-bisphosphate
95°C
Thermotoga maritima
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Archaeoglobus fulgidus
-
Thermotoga maritima
expressed in Escherichia coli
Methanocaldococcus jannaschii
Crystallization (Commentary) (protein specific)
Crystallization
Organism
hanging drop vapour diffusion method, best crystals in the presence of Zn2+ and phosphate
Methanocaldococcus jannaschii
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.038
-
D-fructose 1,6-bisphosphate
85°C
Methanocaldococcus jannaschii
0.07
-
myo-inositol 1-phosphate
37°C
Escherichia coli
0.091
-
myo-inositol 1-phosphate
85°C
Methanocaldococcus jannaschii
0.11
-
myo-inositol 1-phosphate
85°C
Archaeoglobus fulgidus
0.13
-
myo-inositol 1-phosphate
95°C
Thermotoga maritima
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-fructose 1,6-bisphosphate + H2O
Methanocaldococcus jannaschii
very effective substrate
D-fructose 6-phosphate + phosphate
-
Methanocaldococcus jannaschii
?
D-fructose 1,6-bisphosphate + H2O
Archaeoglobus fulgidus
very effective substrate
D-fructose 6-phosphate + phosphate
-
Archaeoglobus fulgidus
?
D-fructose 1,6-bisphosphate + H2O
Thermotoga maritima
very effective substrate
D-fructose 6-phosphate + phosphate
-
Thermotoga maritima
?
D-fructose 1,6-bisphosphate + H2O
Thermotoga maritima TM1415
very effective substrate
D-fructose 6-phosphate + phosphate
-
Thermotoga maritima TM1415
?
D-fructose 1,6-bisphosphate + H2O
Archaeoglobus fulgidus AF2372
very effective substrate
D-fructose 6-phosphate + phosphate
-
Archaeoglobus fulgidus AF2372
?
myo-inositol 1-phosphate + H2O
Escherichia coli
-
myo-inositol + phosphate
-
Escherichia coli
?
myo-inositol 1-phosphate + H2O
Methanocaldococcus jannaschii
organism do not contain lipids with inositol head group, involved in the response to thermal stress
myo-inositol + phosphate
-
Methanocaldococcus jannaschii
?
myo-inositol 1-phosphate + H2O
Archaeoglobus fulgidus
organism do not contain lipids with inositol head group, involved in the response to thermal stress
myo-inositol + phosphate
-
Archaeoglobus fulgidus
?
myo-inositol 1-phosphate + H2O
Thermotoga maritima
organism do not contain lipids with inositol head group, involved in the response to thermal stress
myo-inositol + phosphate
-
Thermotoga maritima
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Thermotoga maritima
-
Archaeoglobus fulgidus
-
Methanocaldococcus jannaschii
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2'-AMP + H2O
600% of the rate with inositol 1-phosphate
653307
Methanocaldococcus jannaschii
adenosine + phosphate
-
653307
Methanocaldococcus jannaschii
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Methanocaldococcus jannaschii
4-nitrophenol + phosphate
-
653307
Methanocaldococcus jannaschii
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus
4-nitrophenol + phosphate
-
653307
Archaeoglobus fulgidus
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Thermotoga maritima
4-nitrophenol + phosphate
-
653307
Thermotoga maritima
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Thermotoga maritima TM1415
4-nitrophenol + phosphate
-
653307
Thermotoga maritima TM1415
?
4-nitrophenyl phosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus AF2372
4-nitrophenol + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Methanocaldococcus jannaschii
alpha-D-glucose + phosphate
-
653307
Methanocaldococcus jannaschii
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus
alpha-D-glucose + phosphate
-
653307
Archaeoglobus fulgidus
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Thermotoga maritima
alpha-D-glucose + phosphate
-
653307
Thermotoga maritima
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Thermotoga maritima TM1415
alpha-D-glucose + phosphate
-
653307
Thermotoga maritima TM1415
?
alpha-D-glucose 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus AF2372
alpha-D-glucose + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Methanocaldococcus jannaschii
D-fructose 6-phosphate + phosphate
-
653307
Methanocaldococcus jannaschii
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus
D-fructose 6-phosphate + phosphate
-
653307
Archaeoglobus fulgidus
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Thermotoga maritima
D-fructose 6-phosphate + phosphate
-
653307
Thermotoga maritima
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Thermotoga maritima TM1415
D-fructose 6-phosphate + phosphate
-
653307
Thermotoga maritima TM1415
?
D-fructose 1,6-bisphosphate + H2O
very effective substrate
653307
Archaeoglobus fulgidus AF2372
D-fructose 6-phosphate + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
D-fructose 2,6-bisphosphate + H2O
16% of the rate with inositol 1-phosphate
653307
Methanocaldococcus jannaschii
D-fructose 6-phosphate + phosphate
-
653307
Methanocaldococcus jannaschii
?
glycerol 2-phosphate + H2O
-
653307
Methanocaldococcus jannaschii
glycerol + phosphate
-
653307
Methanocaldococcus jannaschii
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Archaeoglobus fulgidus
?
-
653307
Archaeoglobus fulgidus
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Thermotoga maritima
?
-
653307
Thermotoga maritima
?
additional information
D-glucose 6-phosphate, D-fructose 6-phosphate, 5'-AMP and NAD+ are not hydrolyzed
653307
Methanocaldococcus jannaschii
?
-
653307
Methanocaldococcus jannaschii
?
additional information
traces of activity with glucose 1-phosphate, no activity with 4-nitrophenyl phosphate and fructose 1,6-bisphosphate
653307
Escherichia coli
?
-
653307
Escherichia coli
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Thermotoga maritima TM1415
?
-
653307
Thermotoga maritima TM1415
?
additional information
archeal enzyme displays inositol monophosphatase as well as fructose 1,6-bisphosphatase activity
653307
Archaeoglobus fulgidus AF2372
?
-
653307
Archaeoglobus fulgidus AF2372
?
myo-inositol 1-phosphate + H2O
-
653307
Escherichia coli
myo-inositol + phosphate
-
653307
Escherichia coli
?
myo-inositol 1-phosphate + H2O
-
653307
Methanocaldococcus jannaschii
myo-inositol + phosphate
-
653307
Methanocaldococcus jannaschii
?
myo-inositol 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus
myo-inositol + phosphate
-
653307
Archaeoglobus fulgidus
?
myo-inositol 1-phosphate + H2O
-
653307
Thermotoga maritima
myo-inositol + phosphate
-
653307
Thermotoga maritima
?
myo-inositol 1-phosphate + H2O
organism do not contain lipids with inositol head group, involved in the response to thermal stress
653307
Methanocaldococcus jannaschii
myo-inositol + phosphate
-
653307
Methanocaldococcus jannaschii
?
myo-inositol 1-phosphate + H2O
organism do not contain lipids with inositol head group, involved in the response to thermal stress
653307
Archaeoglobus fulgidus
myo-inositol + phosphate
-
653307
Archaeoglobus fulgidus
?
myo-inositol 1-phosphate + H2O
organism do not contain lipids with inositol head group, involved in the response to thermal stress
653307
Thermotoga maritima
myo-inositol + phosphate
-
653307
Thermotoga maritima
?
myo-inositol 1-phosphate + H2O
-
653307
Thermotoga maritima TM1415
myo-inositol + phosphate
-
653307
Thermotoga maritima TM1415
?
myo-inositol 1-phosphate + H2O
-
653307
Archaeoglobus fulgidus AF2372
myo-inositol + phosphate
-
653307
Archaeoglobus fulgidus AF2372
?
myo-inositol 2-phosphate + H2O
15% of the rate with inositol 1-phosphate
653307
Methanocaldococcus jannaschii
myo-inositol + phosphate
-
653307
Methanocaldococcus jannaschii
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Archaeoglobus fulgidus
dimer
crystal structure analysis
Methanocaldococcus jannaschii
monomer
-
Escherichia coli
tetramer
-
Thermotoga maritima
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.5
-
myo-inositol 1-phosphate
50°C
Methanocaldococcus jannaschii
2.5
-
myo-inositol 1-phosphate
85°C
Archaeoglobus fulgidus
2.7
-
D-fructose 1,6-bisphosphate
85°C
Archaeoglobus fulgidus
2.7
-
D-fructose 1,6-bisphosphate
50°C
Methanocaldococcus jannaschii
4.2
-
myo-inositol 1-phosphate
85°C
Methanocaldococcus jannaschii
6.5
-
myo-inositol 1-phosphate
37°C
Escherichia coli
7
-
D-fructose 1,6-bisphosphate
85°C
Methanocaldococcus jannaschii
207
-
myo-inositol 1-phosphate
95°C
Thermotoga maritima
268
-
D-fructose 1,6-bisphosphate
95°C
Thermotoga maritima
Other publictions for EC 3.1.3.25
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749526
Murry
Crosstalk between Ras and ino ...
Schizophyllum commune
Adv. Biol. Regul.
72
S2212
2019
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1
1
1
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749540
Rafikov
Inositol monophosphatase 1 as ...
Rattus norvegicus
Am. J. Physiol. Lung Cell Mol. Physiol.
316
L428-L444
2019
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1
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747666
Lu
Production of myo-inositol fr ...
Escherichia coli
Enzyme Microb. Technol.
112
1-5
2018
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1
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749477
Goswami
Inositol monophosphatase A bi ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
ACS Omega
3
13876-13881
2018
-
-
1
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6
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1
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3
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6
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2
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749505
Kraft
Co-crystallization of human i ...
Homo sapiens
Acta Crystallogr. Sect. D
74
973-978
2018
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1
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1
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751088
Ruszkowski
Structural studies of Medicag ...
Medicago truncatula
J. Biol. Chem.
291
9960-9973
2016
-
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1
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3
1
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4
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1
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3
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1
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1
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-
2
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1
1
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1
1
751618
Figueiredo
A homozygous loss-of-function ...
Homo sapiens
Mol. Psychiatry
21
1125-1129
2016
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1
1
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1
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2
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752201
Ferruz
Multibody cofactor and substr ...
Homo sapiens
Sci. Rep.
6
30275
2016
-
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750664
Nourbakhsh
Characterization of the inosi ...
Arabidopsis thaliana
Front. Plant Sci.
5
725
2015
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2
1
1
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4
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1
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1
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1
1
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1
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5
1
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2
1
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1
1
-
2
2
751172
Nakatsu
Sac2/INPP5F is an inositol 4- ...
Mus musculus
J. Cell Biol.
209
85-95
2015
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1
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1
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1
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1
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2
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1
1
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751280
Agam
Calbindin D28k and S100B have ...
Homo sapiens
J. Med. Chem.
58
2042-2044
2015
2
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1
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729719
Dutta
Structural elucidation of the ...
Staphylococcus aureus, Staphylococcus aureus MSSA476
FEBS J.
281
5309-5324
2014
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1
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4
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4
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2
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2
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1
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4
2
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1
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2
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1
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2
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730259
Wang
ONIOM (DFT:MM) study of the ca ...
Bos taurus
J. Phys. Chem. B
117
833-842
2013
-
-
-
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2
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1
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1
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1
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1
1
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2
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1
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1
1
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-
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-
728892
Singh
Cloning, expression, purificat ...
Homo sapiens, Mus musculus
Acta Crystallogr. Sect. F
68
1149-1152
2012
-
-
2
2
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-
2
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1
-
5
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2
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1
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2
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2
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2
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1
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2
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1
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729644
Wang
The inositol monophosphatase A ...
Anabaena sp., Anabaena sp. PCC 7120
Environ. Microbiol. Rep.
4
622-632
2012
-
-
1
-
-
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2
-
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1
-
2
-
20
-
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1
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4
-
1
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-
1
-
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1
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1
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-
1
2
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-
1
-
2
-
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-
1
-
-
-
-
4
-
1
-
-
-
1
-
-
-
1
1
1
1
-
-
729804
Kimata
Synaptic polarity depends on p ...
Caenorhabditis elegans
Genetics
191
509-521
2012
-
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1
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1
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1
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2
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2
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1
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1
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1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
729888
Haimovich
Determination of the lithium b ...
Escherichia coli
J. Am. Chem. Soc.
134
5647-5651
2012
-
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1
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2
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1
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1
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3
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1
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1
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1
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2
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1
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1
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1
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1
-
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-
730109
Lu
Insights into the role of magn ...
Bos taurus
J. Chem. Inf. Model.
52
2398-2409
2012
-
-
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1
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1
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1
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1
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1
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1
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1
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1
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1
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713666
Bhattacharyya
Cloning, overexpression, purif ...
Staphylococcus aureus, Staphylococcus aureus MSSA476
Acta Crystallogr. Sect. F
67
471-474
2011
-
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1
1
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5
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1
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1
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1
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1
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-
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715970
Fujita
In silico study on the substra ...
Homo sapiens
J. Mol. Model.
17
2559-2567
2011
-
-
-
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1
2
5
-
3
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-
-
-
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10
2
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1
2
5
-
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-
-
-
-
10
2
-
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-
-
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-
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-
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716043
Sato
Expression and functions of my ...
Arabidopsis thaliana
J. Plant Res.
124
385-394
2011
-
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1
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3
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4
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6
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3
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3
-
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-
3
-
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-
-
-
16
-
-
3
-
-
-
-
-
-
-
-
-
-
3
9
-
-
-
705858
Andreassi
An NGF-responsive element targ ...
Rattus norvegicus
Nat. Neurosci.
13
291-301
2010
-
-
-
-
-
-
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1
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2
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1
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-
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714620
Movahedzadeh
Inositol monophosphate phospha ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, ATCC 25618
BMC Microbiol.
10
50
2010
-
-
1
-
2
-
-
-
-
-
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2
-
5
-
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4
-
1
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1
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1
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2
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2
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-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
714937
Kalujnaia
A role for inositol monophosph ...
Anguilla anguilla
FASEB J.
24
3981-3991
2010
-
-
1
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-
-
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1
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3
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2
-
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2
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1
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1
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-
1
-
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-
-
-
-
2
-
-
-
2
-
-
-
-
1
-
-
-
1
1
1
1
-
-
716857
Li
Mobile loop mutations in an ar ...
Methanocaldococcus jannaschii
Protein Sci.
19
309-318
2010
-
-
-
1
4
-
3
-
-
2
-
1
-
3
-
-
-
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-
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-
1
-
1
-
1
-
-
-
-
-
-
-
2
-
-
-
-
1
4
-
2
3
-
-
-
2
-
1
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
700488
Siddique
Myo-inositol oxygenase genes a ...
Arabidopsis thaliana
New Phytol.
184
457-472
2009
-
-
1
-
-
-
-
-
-
-
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3
-
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2
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3
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6
-
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-
-
-
-
-
-
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-
-
-
-
-
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701707
Kalujnaia
Regulation of expression of th ...
Anguilla anguilla
Ann. N. Y. Acad. Sci.
1163
433-436
2009
-
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-
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4
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2
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2
-
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-
-
-
-
-
-
-
-
1
-
-
1
-
-
694700
Fu
Barley (Hordeum vulgare L.) in ...
Hordeum vulgare
Plant Mol. Biol.
67
629-642
2008
-
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1
-
-
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2
1
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1
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3
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1
-
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3
1
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3
1
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1
-
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1
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-
1
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-
-
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2
1
1
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-
1
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1
-
3
1
-
3
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
677696
Fukuda
NADP(H) phosphatase activities ...
Archaeoglobus fulgidus, Escherichia coli, Methanocaldococcus jannaschii
Appl. Environ. Microbiol.
73
5447-5452
2007
-
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3
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2
2
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1
2
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9
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2
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-
21
2
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-
2
-
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2
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3
-
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-
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2
2
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2
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1
2
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2
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-
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21
2
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-
2
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678426
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Inositol-1 (or 4)-monophosphat ...
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Biochim. Biophys. Acta
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2007
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1
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2
2
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5
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1
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1
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Kinetic mechanism of the Zn-de ...
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678948
Brown
Dimerization of inositol monop ...
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2
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2
2
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Crystal structure of the tetra ...
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1
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2
1
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The structure of the R184A mut ...
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11
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6
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1
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1
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2
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681812
Miller
myo-inositol monophosphatase: ...
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4
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4
6
1
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1
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9
1
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Patra
Functional identification of s ...
Synechocystis sp.
Planta
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1
1
1
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1
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1
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1
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1
2
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1
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1
1
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1
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1
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1
1
1
-
1
-
1
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682761
Arai
Crystal structure of human myo ...
Homo sapiens
Proteins
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1
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2
1
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663892
Gu
Rv2131c gene product: an uncon ...
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Biochem. Biophys. Res. Commun.
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1
1
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4
1
1
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1
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1
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1
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3
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1
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1
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3
2
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1
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4
1
1
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1
-
1
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664130
Wang
The temperature dependence of ...
Archaeoglobus fulgidus, Methanocaldococcus jannaschii, Thermotoga maritima
Biochemistry
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2006
1
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3
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7
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1
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11
3
3
1
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10
3
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1
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3
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2
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5
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3
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4
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3
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-
11
3
3
1
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10
3
-
-
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680009
Tanizawa
Inositol monophosphatase regul ...
Caenorhabditis elegans
Genes Dev.
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3296-3310
2006
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1
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4
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1
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1
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1
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1
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663506
Gill
High-resolution structure of m ...
Bos taurus
Acta Crystallogr. Sect. D
61
545-555
2005
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1
1
1
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1
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1
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1
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2
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1
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1
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1
1
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1
1
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1
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1
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1
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1
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1
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1
1
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665443
Kim
Inactivation of brain myo-inos ...
Sus scrofa
J. Biochem. Mol. Biol.
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2005
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1
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1
1
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3
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1
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1
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1
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1
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1
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1
1
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3
-
1
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1
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665294
Morgan
Chemistry and biology of deoxy ...
Archaeoglobus fulgidus, Escherichia coli
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2
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14
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2
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14
2
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2
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16
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2
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14
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2
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14
2
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665758
Zheng
High-throughput cell-based scr ...
Homo sapiens
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2004
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1
1
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2
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1
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4
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1
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1
1
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2
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-
-
-
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-
-
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666523
Miller
Removal of the phosphate group ...
Bos taurus
Org. Biomol. Chem.
2
671-688
2004
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22
2
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1
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1
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1
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2
1
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2
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1
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-
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1
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-
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6
-
13
-
-
-
-
-
-
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13
22
6
2
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1
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-
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2
1
-
2
-
1
-
-
-
1
-
-
-
-
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649614
Navarro-Avino
Yeast inositol mono- and trisp ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
302
41-45
2003
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-
-
-
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2
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1
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2
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-
-
-
-
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2
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2
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1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
653807
Stieglitz
Unexpected similarity in regul ...
Archaeoglobus fulgidus, Archaeoglobus fulgidus AF2372, Methanocaldococcus jannaschii, Methanocaldococcus jannaschii MJ0109
Protein Sci.
12
760-767
2003
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2
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1
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2
2
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1
4
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12
-
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2
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12
1
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-
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-
-
-
-
-
-
-
-
-
-
2
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-
1
-
-
2
-
2
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1
4
-
-
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2
-
-
-
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12
1
-
-
-
-
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-
-
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649723
Nigou
Characterization and regulatio ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155
Biochem. J.
361
385-390
2002
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4
2
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2
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2
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12
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1
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4
-
-
-
-
-
1
1
-
-
2
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-
-
-
-
-
-
-
-
-
4
2
2
-
2
-
2
-
-
-
-
-
-
1
-
4
-
-
-
-
-
1
1
-
-
-
-
-
-
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650150
Nigou
Purification and biochemical c ...
Mycobacterium tuberculosis
Biochemistry
41
4392-4398
2002
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1
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6
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9
1
-
4
3
1
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5
-
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1
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-
-
-
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7
1
1
1
1
1
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
9
-
1
-
4
3
1
-
-
-
1
-
-
-
-
7
1
1
1
1
1
1
-
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652323
Berggard
Myo-inositol monophosphatase i ...
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J. Biol. Chem.
277
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2002
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1
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1
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2
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
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652735
Fauroux
Stereochemistry at phosphorus ...
Bos taurus
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1363-1373
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2
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1
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4
1
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-
-
2
-
1
-
-
1
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-
-
-
-
-
-
-
-
-
2
1
2
-
1
1
1
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-
-
-
-
1
-
-
4
1
-
-
-
2
-
1
-
-
-
-
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-
653194
Bahn
Production of monoclonal antib ...
Sus scrofa
Mol. Cell
13
21-27
2002
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1
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1
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1
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2
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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1
1
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
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722624
Stieglitz
Crystal structure of a dual ac ...
Archaeoglobus fulgidus
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1
1
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3
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1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
1
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
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649506
Janczarek
The Rhizobium leguminosarum bv ...
Rhizobium leguminosarum
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1
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1
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1
1
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1
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-
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6
-
-
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-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
1
-
5
1
1
-
-
-
1
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
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650066
Johnson
Crystal structure and catalyti ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661
Biochemistry
40
618-630
2001
-
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1
1
-
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3
-
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3
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1
-
5
-
-
1
-
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
3
-
-
-
3
-
1
-
-
-
1
-
-
-
-
10
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649972
Chen
Overexpression, purification, ...
Archaeoglobus fulgidus, Escherichia coli, Methanocaldococcus jannaschii, Thermotoga maritima
Biochemistry
39
4145-4153
2000
-
-
4
-
1
-
1
2
-
7
4
4
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10
-
-
1
-
-
-
1
-
8
1
1
1
1
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
1
-
2
-
7
4
4
-
-
-
1
-
-
1
-
8
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
653266
Murray
Expression of yeast INM1 encod ...
Saccharomyces cerevisiae
Mol. Microbiol.
36
651-661
2000
1
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1
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-
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2
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-
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2
1
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3
-
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1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
-
-
2
1
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653307
Stec
MJ0109 is an enzyme that is bo ...
Archaeoglobus fulgidus, Archaeoglobus fulgidus AF2372, Escherichia coli, Methanocaldococcus jannaschii, Thermotoga maritima, Thermotoga maritima TM1415
Nat. Struct. Biol.
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3
1
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9
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8
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3
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34
4
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-
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9
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
5
-
-
-
9
-
-
-
3
-
-
-
-
34
4
-
-
-
9
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myo-Inositol monophosphatase f ...
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Ganzhorn
Structural characterization of ...
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Biochim. Biophys. Acta
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1993
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Characterization of inositol m ...
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Purification and properties of ...
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Parhasarathy
The effects of lithium isotope ...
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cDNA cloning of human and rat ...
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The identification of a membra ...
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Purification and properties of ...
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Shute
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1988
626-628
1988
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Shute
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Mechanism of the myo-inositol ...
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Ragan
The dephosphorylation of inosi ...
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1988
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Carey
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1988
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Creba
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Metabolism of inositol 1-phosp ...
Homo sapiens
Biochem. Soc. Trans.
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557-558
1988
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vom Dahl
Hepatic inositol release upon ...
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Biochem. J.
251
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1988
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Use of lithium ion in measurem ...
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The effects of lithium on plat ...
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