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Literature summary for 3.1.3.25 extracted from
- Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate (2000), Mol. Microbiol., 36, 651-661.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | expression is increased in the presence of inositol | Saccharomyces cerevisiae |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Li+ | - |
Saccharomyces cerevisiae |  |
| additional information | Li+, glycerol and glucose in the culture medium depresses enzyme expression, no inhibition with valproate | Saccharomyces cerevisiae |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 31800 | - |
calculated from amino acid sequence | Saccharomyces cerevisiae |
| 32000 | - |
SDS-PAGE | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myo-inositol 1-phosphate + H2O | Saccharomyces cerevisiae | de novo biosynthesis of inositol, involved in phosphoinositide signaling pathway | myo-inositol + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant protein from Escherichia coli | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no activity with glucose 6-phosphate and 5'-AMP | Saccharomyces cerevisiae | ? | - |
? | |
| myo-inositol 1,4-bisphosphate + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
| myo-inositol 1-phosphate + H2O | D- and L-isomer serve as substrate | Saccharomyces cerevisiae | myo-inositol + phosphate | - |
? | |
| myo-inositol 1-phosphate + H2O | de novo biosynthesis of inositol, involved in phosphoinositide signaling pathway | Saccharomyces cerevisiae | myo-inositol + phosphate | - |
? | |
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