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Literature summary for 3.1.3.25 extracted from

  • Kwon, H.Y.; Lim, B.H.; Park, H.S.; Lee, Y.L.; Lee, E.H.; Choi, S.Y.; Park, H.J.
    Rat duodenal mucosa inositol monophosphatase; novel enzyme of which properties are distinct from brain enzyme (1998), J. Biochem. Mol. Biol., 31, 274-280.
No PubMed abstract available
Search for more literature for 3.1.3.25

Inhibitors

Inhibitors Comment Organism Structure
Li+ at 100 mM 72% inhibition of the brain enzyme but only 27% of the duodenal enzyme Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 DL-myo-inositol 1-phosphate brain IMPase Rattus norvegicus
0.15
-
 DL-myo-inositol 1-phosphate duodenal IMPase Rattus norvegicus
0.2
-
 Glycerol 2-phosphate duodenal IMPase Rattus norvegicus
0.34
-
 Glycerol 2-phosphate brain IMPase Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ duodenal IMPase is less dependent on Mg2+ than the brain one Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
 2 * 24000, SDS-PAGE Rattus norvegicus
48000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
223fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
duodenal mucosa
-
 Rattus norvegicus
-
ileal mucosa
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-
pancreas
-
 Rattus norvegicus
-
stomach
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-AMP + H2O
-
 Rattus norvegicus adenosine + phosphate
-
 ?
4-nitrophenyl phosphate + H2O
-
 Rattus norvegicus 4-nitrophenol + phosphate
-
 ?
DL-myo-inositol 1-phosphate + H2O
-
 Rattus norvegicus DL-myo-inositol + phosphate
-
 ?
glycerol 2-phosphate + H2O
-
 Rattus norvegicus glycerol + phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 24000, SDS-PAGE Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
75
-
 for 10 min, the duodenal enzyme retains only 27% of activity, the brain enzyme 67% Rattus norvegicus