Literature summary for 3.1.3.2 extracted from

Alimoradi, N.; Ashrafi-Kooshk, M.R.; Shahlaei, M.; Maghsoudi, S.; Adibi, H.; McGeary, R.P.; Khodarahmi, R.
Diethyl (alkylsulfonamido(4-methoxyphenyl)methyl)phosphonate/phosphonic acid derivatives act as acid phosphatase inhibitors synthesis accompanied by experimental and molecular modeling assessments (2017), J. Enzyme Inhib. Med. Chem., 32, 20-28 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
((4-methoxyphenyl)(octylsulfonamido)methyl)phosphonic acid	very weak inhibitor	Phaseolus vulgaris
(dodecylsulfonamido(4-methoxyphenyl)methyl)phosphonic acid	-	Phaseolus vulgaris
(hexadecylsulfonamido(4-methoxyphenyl)methyl)phosphonic acid	-	Phaseolus vulgaris
(hexylsulfonamido(4-methoxyphenyl)methyl)phosphonic acid	very weak inhibitor	Phaseolus vulgaris
Diethyl (hexadecylsulfonamido(4-methoxyphenyl)methyl)phosphonate	-	Phaseolus vulgaris
diethyl((4-methoxyphenyl)(octylsulfonamido)methyl)phosphonate	very weak inhibitor	Phaseolus vulgaris
diethyl(dodecylsulfonamido(4-methoxyphenyl)methyl)phosphonate	-	Phaseolus vulgaris
diethyl(hexadecylsulfonamido(4-methoxyphenyl)methyl)phosphonate	-	Phaseolus vulgaris
diethyl(hexylsulfonamido(4-methoxyphenyl)methyl)phosphonate	very weak inhibitor	Phaseolus vulgaris
L-Tartrate	-	Phaseolus vulgaris

Organism

Organism	UniProt	Comment	Textmining
Phaseolus vulgaris	-	red kidney bean	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl phosphate + H2O	-	Phaseolus vulgaris	4-nitrophenol + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PAP	-	Phaseolus vulgaris
purple acid phosphatase	-	Phaseolus vulgaris

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0011	-	(hexadecylsulfonamido(4-methoxyphenyl)methyl)phosphonic acid	at pH 4.9 and 25°C	Phaseolus vulgaris
0.013	-	diethyl(hexadecylsulfonamido(4-methoxyphenyl)methyl)phosphonate	at pH 4.9 and 25°C	Phaseolus vulgaris
0.095	-	(dodecylsulfonamido(4-methoxyphenyl)methyl)phosphonic acid	at pH 4.9 and 25°C	Phaseolus vulgaris
0.202	-	diethyl(dodecylsulfonamido(4-methoxyphenyl)methyl)phosphonate	at pH 4.9 and 25°C	Phaseolus vulgaris
0.783	-	L-Tartrate	at pH 4.9 and 25°C	Phaseolus vulgaris

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.013	-	at pH 4.9 and 25°C	Phaseolus vulgaris	(hexadecylsulfonamido(4-methoxyphenyl)methyl)phosphonic acid
0.092	-	at pH 4.9 and 25°C	Phaseolus vulgaris	diethyl(hexadecylsulfonamido(4-methoxyphenyl)methyl)phosphonate
0.421	-	at pH 4.9 and 25°C	Phaseolus vulgaris	(dodecylsulfonamido(4-methoxyphenyl)methyl)phosphonic acid
0.759	-	at pH 4.9 and 25°C	Phaseolus vulgaris	diethyl(dodecylsulfonamido(4-methoxyphenyl)methyl)phosphonate
3.315	-	at pH 4.9 and 25°C	Phaseolus vulgaris	L-Tartrate

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Release 2023.1 (January 2023)