Literature summary for 3.1.3.2 extracted from

Vovk, A.I.; Mischenko, I.M.; Tanchuk, V.Y.; Kachkovskii, G.A.; Sheiko, S.Y.; Kolodyazhnyi, O.I.; Kukhar, V.P.
Stereoselectivity of binding of alpha-(N-benzylamino)benzylphosphonic acids to prostatic acid phosphatase (2008), Bioorg. Med. Chem. Lett., 18, 4620-4623.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(1R)-1-phenyl-N-[(S)-phenyl(phosphono)methyl]ethanaminium chloride	-	Homo sapiens
(1R)-N-[(S)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride	-	Homo sapiens
(1S)-1-phenyl-N-[(R)-phenyl(phosphono)methyl]ethanaminium chloride	-	Homo sapiens
(1S)-N-[(R)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride	-	Homo sapiens
(R)-N-benzyl(phenyl)phosphonomethanaminium chloride	-	Homo sapiens
(S)-N-benzyl(phenyl)phosphonomethanaminium chloride	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.14	-	1-naphthyl phosphate	-	Homo sapiens
1.95	-	O-phospho-L-tyrosine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15309	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-naphthyl phosphate + H2O	-	Homo sapiens	1-naphthol + phosphate	-	?
O-phospho-L-tyrosine + H2O	-	Homo sapiens	phosphate + L-tyrosine	-	?

Synonyms

Synonyms	Comment	Organism
acid phosphatase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000005	-	determined by O-phosphotyrosine enzyme assay	Homo sapiens	(R)-N-benzyl(phenyl)phosphonomethanaminium chloride
0.000018	-	determined by O-phosphotyrosine enzyme assay	Homo sapiens	(1S)-N-[(R)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride
0.000026	-	determined by O-phosphotyrosine enzyme assay	Homo sapiens	(1S)-1-phenyl-N-[(R)-phenyl(phosphono)methyl]ethanaminium chloride
0.000198	-	determined by O-phosphotyrosine enzyme assay	Homo sapiens	(S)-N-benzyl(phenyl)phosphonomethanaminium chloride
0.00107	-	determined by O-phosphotyrosine enzyme assay	Homo sapiens	(1R)-N-[(S)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride
0.00121	-	determined by O-phosphotyrosine enzyme assay	Homo sapiens	(1R)-1-phenyl-N-[(S)-phenyl(phosphono)methyl]ethanaminium chloride

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Release 2023.1 (January 2023)