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Literature summary for 3.1.3.2 extracted from
- Tartrate-inhibitable acid phosphatase. Purification from placenta, characterization and subcellular distribution in fibroblasts (1984), Hoppe-Seyler's Z. Physiol. Chem., 365, 651-660.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| phosphate | - |
Homo sapiens |  |
| Tartrate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
p-nitrophenyl phosphate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
| additional information | light membrane-fraction | Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
2 * 48000, urinary enzyme, SDS-PAGE | Homo sapiens |
| 90000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | each subunit carries one oligosaccharide of the high-mannose/hybride type | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| isoenzyme A, B and C 103 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | normal and mucolipidosis II fibroblasts | Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 236 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 50% glycerol, 15 months, stable | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AMP + H2O | - |
Homo sapiens | adenosine + phosphate | - |
? | |
| ATP + H2O | no activity | Homo sapiens | ADP + phosphate | - |
? | |
| diphosphate + H2O | no activity | Homo sapiens | 2 phosphate | - |
? | |
| Glucose 6-phosphate + H2O | - |
Homo sapiens | Glucose + phosphate | - |
? | |
| NADP+ + H2O | no activity | Homo sapiens | NAD+ + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? | |
| UTP + 2 H2O | no activity | Homo sapiens | UMP + 2 phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 48000, urinary enzyme, SDS-PAGE | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
20 h, stable | Homo sapiens |
| 37 | - |
20 h, 27% loss of activity | Homo sapiens |
| 50 | - |
90 min, 74% loss of activity | Homo sapiens |
| 70 | - |
10 min, more than 95% loss of activity | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
- |
Homo sapiens |
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