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Literature summary for 3.1.3.16 extracted from

  • LeMaire, S.; Raghuram, V.; Grady, C.R.; Pickering, C.M.; Chou, C.-L.; Umejiego, E.N.; Knepper, M.A.
    Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct (2017), Am. J. Physiol. Renal. Physiol., 312, F84-F95 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[aquaporin-2]-serine/threonine phosphate + H2O Mus musculus
-
 [aquaporin-2]-serine/threonine + phosphate
-
 ?
[aquaporin-2]-serine/threonine phosphate + H2O Rattus norvegicus
-
 [aquaporin-2]-serine/threonine + phosphate
-
 ?
[aquaporin-2]-serine/threonine phosphate + H2O Rattus norvegicus Sprague-Dawley
-
 [aquaporin-2]-serine/threonine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney cortical collecting ducts Mus musculus
-
kidney inner medullary collecting ducts, proteomic analysis of the cytoplasmic fraction of inner medullary collecting ducts, overview Rattus norvegicus
-
medullary collecting duct
-
 Rattus norvegicus
-
mpkCCD cell a vasopressin-responsive cell culture model of cortical collecting duct, proteomic analysis of cytoplasmic fractions from mpkCCD cells, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[aquaporin-2]-serine/threonine phosphate + H2O
-
 Mus musculus [aquaporin-2]-serine/threonine + phosphate
-
 ?
[aquaporin-2]-serine/threonine phosphate + H2O
-
 Rattus norvegicus [aquaporin-2]-serine/threonine + phosphate
-
 ?
[aquaporin-2]-serine/threonine phosphate + H2O
-
 Rattus norvegicus Sprague-Dawley [aquaporin-2]-serine/threonine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
S/T-phosphatase
-
 Mus musculus
S/T-phosphatase
-
 Rattus norvegicus
serine/threonine phosphatase
-
 Mus musculus
serine/threonine phosphatase
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct. The level of phosphorylation at these sites is determined by a balance between phosphorylation by protein kinases and dephosphorylation by phosphatases. Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct, overview Mus musculus
physiological function phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct. The level of phosphorylation at these sites is determined by a balance between phosphorylation by protein kinases and dephosphorylation by phosphatases. Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct, overview Rattus norvegicus