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Literature summary for 3.1.3.16 extracted from
- A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5 (2014), J. Biol. Chem., 289, 25137-25148 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| W58A/D59A | the mutant shows markedly reduced activity compared to the wild type enzyme | Homo sapiens |
| W58A/D59A/W62A/D63A | the mutant shows markedly reduced activity compared to the wild type enzyme | Homo sapiens |
| W62A/D63A | the mutant shows markedly reduced activity compared to the wild type enzyme | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.023 | - |
NFEDHpSAPPSP | at pH 7.5 and, temperature not specified in the publication | Homo sapiens |  |
| 0.026 | - |
HSAPPpSPEEKD | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.028 | - |
WHLADpSPAVNG | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.05 | - |
ESEMEpTPSAIN | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.065 | - |
NPCTEpTFTGTL | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.072 | - |
DDApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.098 | - |
PVARTpSPLQTP | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.113 | - |
ENDpTINASL | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.114 | - |
ASQEPpSPAASA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.206 | - |
AAApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.237 | - |
YLRSIpSLPVPV | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.357 | - |
AGPALSPVPPV | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.409 | - |
VARKLpSAREQR | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.48 | - |
SQLHIpTPGTAY | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.656 | - |
RGRGSpSVGGGS | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.354 | - |
RRApSVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.954 | - |
RRApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 2.749 | - |
ALSAGpSNEYLR | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 600000 | - |
light scattering | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q96HS1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AAApTVA + H2O | - |
Homo sapiens | AAATVA + phosphate | - |
? | |
| AGPALpSPVPPV + H2O | - |
Homo sapiens | AGPALSPVPPV + phosphate | - |
? | |
| ALSAGpSNEYLR + H2O | - |
Homo sapiens | ALSAGSNEYLR + phosphate | - |
? | |
| ASQEPpSPAASA + H2O | - |
Homo sapiens | ASQEPSPAASA + phosphate | - |
? | |
| DDApTVA + H2O | - |
Homo sapiens | DDATVA + phosphate | - |
? | |
| ENDpTINASL + H2O | - |
Homo sapiens | ENDTINASL + phosphate | - |
? | |
| ESEMEpTPSAIN + H2O | - |
Homo sapiens | ESEMETPSAIN + phosphate | - |
? | |
| HSAPPpSPEEKD + H2O | - |
Homo sapiens | HSAPPSPEEKD + phosphate | - |
? | |
| additional information | no activity with RRAYVA, ENDYINASL, DADEYLIPQQG, DPVARTSPLQT, PIMPASPQKGH, and EVFCFSQRRKE | Homo sapiens | ? | - |
? | |
| NFEDHpSAPPSP + H2O | - |
Homo sapiens | NFEDHSAPPSP + phosphate | - |
? | |
| NPCTEpTFTGTL + H2O | - |
Homo sapiens | NPCTETFTGTL + phosphate | - |
? | |
| PVARTpSPLQTP + H2O | - |
Homo sapiens | PVARTSPLQTP + phosphate | - |
? | |
| RGRGSpSVGGGS + H2O | - |
Homo sapiens | RGRGSSVGGGS + phosphate | - |
? | |
| RRApSVA + H2O | - |
Homo sapiens | RRASVA + phosphate | - |
? | |
| RRApTVA + H2O | - |
Homo sapiens | RRATVA + phosphate | - |
? | |
| SQLHIpTPGTAY + H2O | - |
Homo sapiens | SQLHITPGTAY + phosphate | - |
? | |
| VARKLpSAREQR + H2O | - |
Homo sapiens | VARKLSAREQR + phosphate | - |
? | |
| WHLADpSPAVNG + H2O | - |
Homo sapiens | WHLADSPAVNG + phosphate | - |
? | |
| YLRSIpSLPVPV + H2O | - |
Homo sapiens | YLRSISLPVPV + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGAM5 | - |
Homo sapiens |
| phosphoglycerate mutase 5 | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
RGRGSpSVGGGS | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.39 | - |
ESEMEpTPSAIN | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.4 | - |
SQLHIpTPGTAY | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.48 | - |
YLRSIpSLPVPV | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.605 | - |
RRApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.62 | - |
ASQEPpSPAASA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.64 | - |
PVARTpSPLQTP | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.65 | - |
ALSAGpSNEYLR | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.86 | - |
HSAPPpSPEEKD | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.86 | - |
VARKLpSAREQR | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.93 | - |
RRApSVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.03 | - |
WHLADpSPAVNG | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.05 | - |
AAApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.16 | - |
NPCTEpTFTGTL | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.2 | - |
ENDpTINASL | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.3 | - |
DDApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.31 | - |
AGPALpSPVPPV | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 1.33 | - |
NFEDHpSAPPSP | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
RGRGSpSVGGGS | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.17 | - |
ALSAGSNEYLR | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.3 | - |
RRApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.7 | - |
RRApSVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 0.8 | - |
SQLHIpTPGTAY | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 2 | - |
YLRSIpSLPVPV | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 2.17 | - |
VARKLpSAREQR | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 3.3 | - |
AGPALpSPVPPV | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 5 | - |
ASQEPpSPAASA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 5.2 | - |
AAApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 6.7 | - |
PVARTpSPLQTP | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 8.3 | - |
ESEMEpTPSAIN | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 10.7 | - |
ENDpTINASL | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 18 | - |
DDApTVA | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 18.3 | - |
NPCTEpTFTGTL | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 31.7 | - |
HSAPPpSPEEKD | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 36.7 | - |
WHLADpSPAVNG | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
| 56.7 | - |
NFEDHpSAPPSP | at pH 7.5 and, temperature not specified in the publication | Homo sapiens | |
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