Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | calcineurin is dependent on Ca2+/calmodulin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-(3,4-dichloro-phenyl)-4-(N,N-dimethylaminoethylthio)-2-phenyl-pyrimidine | i.e. CN585, noncompetitively and reversibly inhibits calcineurin activity, without affecting other Ser/Thr protein phosphatases or peptidyl prolyl cis/trans isomerases. The compound shows potent immunosuppressive effects by inhibiting NFAT nuclear translocation and transactivation, cytokine production, and T cell proliferation | Homo sapiens | |
cyclosporin A | the calcineurin inhibitor can block T-cell activation and is used as immunosuppressiv drug to prevent graft-versus-host reactions and autoimmune diseases | Homo sapiens | |
FK506 | the calcineurin inhibitor can block T-cell activation and is used as immunosuppressive drug to prevent graft-versus-host reactions and autoimmune diseases | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calcineurin is dependent on Ca2+/calmodulin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | - |
Homo sapiens | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0038 | - |
6-(3,4-dichloro-phenyl)-4-(N,N-dimethylaminoethylthio)-2-phenyl-pyrimidine | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the Ca2+/calmodulin-dependent protein phosphatase calcineurin is a key mediator in antigen-specific T-cell activation | Homo sapiens |