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Literature summary for 3.1.3.16 extracted from

  • Van Kanegan, M.J.; Strack, S.
    The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation (2009), Mol. Cell. Biol., 29, 662-674.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid complete inhibition at 250 nM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated tropomyosin-related kinase A + H2O two neuron-enriched regulatory subunits, B'beta and B'delta, recruit PP2A into a complex with tropomyosin-related kinase A to dephosphorylate the nerve growth factor receptor on Ser/Thr residues and to potentiate its intrinsic tyrosine kinase activity Rattus norvegicus tropomyosin-related kinase A + phosphate
-
?

Subunits

Subunits Comment Organism
heterotrimer
-
Rattus norvegicus

Synonyms

Synonyms Comment Organism
PP2A
-
Rattus norvegicus
protein phosphatase 2A
-
Rattus norvegicus