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Literature summary for 3.1.3.16 extracted from

  • Pulido, R.; Hooft van Huijsduijnen, R.
    Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease (2008), FEBS J., 275, 848-866.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ERK-2 association with ERK-2 results in catalytic activation of Pac-1 Homo sapiens

Application

Application Comment Organism
medicine MKP-1 inhibitors may have a use in cancer therapy Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-
nucleus MKP-1 is predominantly nuclear Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O95248
-
-
Homo sapiens O95278
-
-
Homo sapiens P28562
-
-
Homo sapiens P60484
-
-
Homo sapiens Q05923
-
-
Homo sapiens Q16828
-
-
Homo sapiens Q93096
-
-
Homo sapiens Q9BV47
-
-
Homo sapiens Q9Y6W6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
Homo sapiens
-
eosinophil
-
Homo sapiens
-
hematopoietic cell
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
mast cell umbilical cord derived mast cell Homo sapiens
-
neuroblastoma cell MKP-8 is highly expressed in neuroblastoma Homo sapiens
-
neuroepithelioma cell MKP-8 is highly expressed in neuroepithelioma Homo sapiens
-
polymorphonuclear cell
-
Homo sapiens
-
retinoblastoma cell MKP-8 is highly expressed in retinoblastoma Homo sapiens
-
Th1-cell
-
Homo sapiens
-
Th2-cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information laforin shows diminished in vitro dephosphorylation of p-nitrophenyl phosphate in the presence of glucose polymers Homo sapiens ?
-
?
additional information malin is an E3 ubiquitin ligase that promotes the degradation of laforin Homo sapiens ?
-
?
additional information MKP-5 does not dephosphorylate ERK Homo sapiens ?
-
?
phosphatidylinositol-(3,4,5)-triphosphate + H2O the enzyme displays activity towards the D3 position of the phosphoinositide second messenger phosphatidylinositol (3,4,5)-triphosphate Homo sapiens ?
-
?
phosphorylated c-Jun N-terminal kinase + H2O
-
Homo sapiens c-Jun N-terminal kinase + phosphate
-
?
phosphorylated ERK + H2O
-
Homo sapiens ERK + phosphate
-
?
phosphorylated ERK + H2O binds heat shock transcription factor 4 in a complex with ERK, controlling transcription factor DNA binding Homo sapiens ERK + phosphate
-
?
phosphorylated ERK-2 + H2O
-
Homo sapiens ERK-2 + phosphate
-
?
phosphorylated ERK-2 + H2O preferred substrate Homo sapiens ERK-2 + phosphate
-
?
phosphorylated GSK3beta + H2O laforin dephosphorylates the inhibitory Ser9 of GSK3beta Homo sapiens GSK3beta + phosphate
-
?
phosphorylated p38 + H2O
-
Homo sapiens p38 + phosphate
-
?
phosphorylated protein kinase CK2alpha + H2O
-
Homo sapiens protein kinase CK2alpha + phosphate
-
?

Synonyms

Synonyms Comment Organism
class I cysteine-based dual-specificity phosphatase cf. EC 3.1.3.48 Homo sapiens
class I cysteine-based dual-specificity phosphatase cf. EC 3.1.3.48 and EC 3.1.3.67 Homo sapiens
DSP PTP domain class I DSPs differ from classical PTPs in that they can dephosphorylate phospho-Tyr, phospho-Ser and phospho-Thr residues, as well as nonproteinaceous substrates Homo sapiens
dual specificity protein phosphatase 1
-
Homo sapiens
dual specificity protein phosphatase 10
-
Homo sapiens
dual specificity protein phosphatase 26
-
Homo sapiens
dual specificity protein phosphatase 6
-
Homo sapiens
DUSP1
-
Homo sapiens
DUSP10
-
Homo sapiens
DUSP26
-
Homo sapiens
DUSP6
-
Homo sapiens
EPM2A
-
Homo sapiens
laforin
-
Homo sapiens
MKP-1
-
Homo sapiens
MKP-5
-
Homo sapiens
MKP-8
-
Homo sapiens
MMAC-1
-
Homo sapiens
MTMR5
-
Homo sapiens
Pac-1
-
Homo sapiens
phosphatase of activated cells 1
-
Homo sapiens
phosphatase of regenerating liver
-
Homo sapiens
PRL-1
-
Homo sapiens
PTEN
-
Homo sapiens
PTP
-
Homo sapiens
PTPCAAX1
-
Homo sapiens
SBF1
-
Homo sapiens
Set-binding factor 1
-
Homo sapiens
TEP1
-
Homo sapiens