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Literature summary for 3.1.3.16 extracted from
- The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A (2005), J. Biol. Chem., 280, 41512-41520.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| in vitro transcription and translation in rabbit reticulocyte extract or expression in Escherichia coli strain BL21 of PP2A subunits | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | subcellular distribution | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the cystic fibrosis transmembrane conductance regulator, a cAMP-activated chloride channel at the apical surface of epithelia, is regulated by a direct interaction with the protein phosphatase 2A | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant subunits | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Calu-3 cell | airway epithelial cell line | Homo sapiens | - |
| epithelium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the cystic fibrosis transmembrane conductance regulator, a cAMP-activated chloride channel at the apical surface of epithelia, is regulated by a direct interaction with the protein phosphatase 2A | Homo sapiens | ? | - |
? | |
| additional information | substrate specificity of PP2A isozymes | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | heterotrimer composed of a catalytic subunit and two divergent regulatory subunits, different subunit variants allow the formation of several different combination, i.e. isozymes | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PP2A | - |
Homo sapiens |
| protein phosphatase 2A | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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