Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fostriecin | - |
Mus musculus | |
okadaic acid | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated IkappaB kinase + H2O | Mus musculus | PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview | IkappaB kinase + phosphate | - |
? | |
phosphorylated IkappaB kinase + H2O | Mus musculus C57BL6 | PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview | IkappaB kinase + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57Bl6 mice | - |
Mus musculus C57BL6 | - |
C57Bl6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | primary | Mus musculus | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated IkappaB kinase + H2O | PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview | Mus musculus | IkappaB kinase + phosphate | - |
? | |
phosphorylated IkappaB kinase + H2O | formation of PP2A-IKK complexes, determination of interaction sites | Mus musculus | IkappaB kinase + phosphate | - |
? | |
phosphorylated IkappaB kinase + H2O | PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview | Mus musculus C57BL6 | IkappaB kinase + phosphate | - |
? | |
phosphorylated IkappaB kinase + H2O | formation of PP2A-IKK complexes, determination of interaction sites | Mus musculus C57BL6 | IkappaB kinase + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP2A | - |
Mus musculus |
protein serine/threonine phosphatase 2A | - |
Mus musculus |