Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | DNA damage 34, i.e. gADD34, and growth arrest disturb the binding of PP1 to p53 | Mus musculus | |
okadaic acid | - |
Homo sapiens | |
okadaic acid | - |
Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | - |
Mus musculus | |
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated p53 + H2O | Mus musculus | dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function | p53 + phosphate | - |
? | |
phosphorylated p53 + H2O | Homo sapiens | dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function | p53 + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
HEK-293 cell | - |
Homo sapiens | - |
MEF cell | embryonic fibroblast cell line from GADD34-deficient mice and from wild-type mice | Mus musculus | - |
WI-38 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated p53 + H2O | dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function | Mus musculus | p53 + phosphate | - |
? | |
phosphorylated p53 + H2O | dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function | Homo sapiens | p53 + phosphate | - |
? | |
phosphorylated p53 + H2O | dephosphorylation of Ser15 by PP1, no activity with PP2A | Mus musculus | p53 + phosphate | - |
? | |
phosphorylated p53 + H2O | dephosphorylation of Ser15 by PP1, no activity with PP2A | Homo sapiens | p53 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP1 | - |
Mus musculus |
PP1 | - |
Homo sapiens |
PP2A | - |
Mus musculus |
PP2A | - |
Homo sapiens |
protein phosphatase 1 | - |
Mus musculus |
protein phosphatase 1 | - |
Homo sapiens |
protein phosphatase 2A | - |
Mus musculus |
protein phosphatase 2A | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |