Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclosporin A | inhibition of phosphatase PfPP2B | Plasmodium falciparum | |
okadaic acid | no inhibition | Plasmodium falciparum | |
Trifluoperazine | inhibition of phosphatase PfPP2B | Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Plasmodium falciparum | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | phosphatase PfPP2B, activated by Ca2+ plus calmodulin | Plasmodium falciparum | |
Ca2+ | phosphatase PfPP2A, Ca2+ can replace Mn2+ in activation | Plasmodium falciparum | |
Mn2+ | required by phosphatase PfPP2A | Plasmodium falciparum | |
Ni2+ | phosphatase PfPP2A, Ni2+ can replace Mn2+ in activation | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | O15920 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocytic stage | - |
Plasmodium falciparum | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.021 | - |
phosphatase PfPP2B | Plasmodium falciparum |
0.13 | - |
phosphatase PfPP2A | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
p-nitrophenyl phosphate + H2O | - |
Plasmodium falciparum | p-nitrophenol + phosphate | - |
? | |
phosphophosphorylase kinase + H2O | specific for alpha-subunit | Plasmodium falciparum | phosphorylase kinase + phosphate | - |
? | |
phosphoproteins + H2O | - |
Plasmodium falciparum | proteins + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PfPP2A | - |
Plasmodium falciparum |
PfPP2B | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | 40 | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | stimulation of phosphatase PfPP2B | Plasmodium falciparum |