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Literature summary for 3.1.3.16 extracted from

  • Dobson, S.; May, T.; Berriman, M.; Del Vecchio, C.; Fairlamb, A.H.; Chakrabarti, D.; Barik, S.
    Characterization of protein Ser/Thr phosphatases of the malaria parasite, Plasmodium falciparum: inhibition of the parasitic calcineurin by cyclophilin-cyclosporin complex (1999), Mol. Biochem. Parasitol., 99, 167-181.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A inhibition of phosphatase PfPP2B Plasmodium falciparum
okadaic acid no inhibition Plasmodium falciparum
Trifluoperazine inhibition of phosphatase PfPP2B Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Plasmodium falciparum 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ phosphatase PfPP2B, activated by Ca2+ plus calmodulin Plasmodium falciparum
Ca2+ phosphatase PfPP2A, Ca2+ can replace Mn2+ in activation Plasmodium falciparum
Mn2+ required by phosphatase PfPP2A Plasmodium falciparum
Ni2+ phosphatase PfPP2A, Ni2+ can replace Mn2+ in activation Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum O15920
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Plasmodium falciparum

Source Tissue

Source Tissue Comment Organism Textmining
erythrocytic stage
-
Plasmodium falciparum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.021
-
phosphatase PfPP2B Plasmodium falciparum
0.13
-
phosphatase PfPP2A Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl phosphate + H2O
-
Plasmodium falciparum p-nitrophenol + phosphate
-
?
phosphophosphorylase kinase + H2O specific for alpha-subunit Plasmodium falciparum phosphorylase kinase + phosphate
-
?
phosphoproteins + H2O
-
Plasmodium falciparum proteins + phosphate
-
?

Synonyms

Synonyms Comment Organism
PfPP2A
-
Plasmodium falciparum
PfPP2B
-
Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37 40
-
Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
Calmodulin stimulation of phosphatase PfPP2B Plasmodium falciparum