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Literature summary for 3.1.3.16 extracted from
- Phosphoprotein phosphatases (1986), The Enzymes, 3rd Ed. (Boyer, P. D. , ed.), 17, 311-361.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| histone | - |
Oryctolagus cuniculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | - |
Oryctolagus cuniculus | |
| N-ethylmaleimide | - |
Oryctolagus cuniculus | |
| p-chloromercuribenzoate | - |
Oryctolagus cuniculus | |
| phosphate | - |
Oryctolagus cuniculus | |
| Zn2+ | - |
Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mammalia | 5737 | - |
| cytoplasm | - |
Oryctolagus cuniculus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required by B subunit of calcineurin, four binding sites | Mammalia | |
| Ca2+ | required by B subunit of calcineurin, four binding sites | Oryctolagus cuniculus | |
| Co2+ | - |
Mammalia | |
| Co2+ | - |
Oryctolagus cuniculus | |
| Mg2+ | - |
Meleagris gallopavo | |
| Mg2+ | - |
Mammalia | |
| Mg2+ | - |
Oryctolagus cuniculus | |
| Mn2+ | activation | Meleagris gallopavo | |
| Mn2+ | activation | Mammalia | |
| Mn2+ | activation | Oryctolagus cuniculus | |
| Mn2+ | depending on source of enzyme and substrate | Mammalia | |
| Mn2+ | depending on source of enzyme and substrate | Oryctolagus cuniculus | |
| Ni2+ | activation | Mammalia | |
| Ni2+ | activation | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | 90000 | phosphatase 2B, i.e. calcineurin, sedimentation equilibrium centrifugation | Mammalia |
| 80000 | 90000 | phosphatase 2B, i.e. calcineurin, sedimentation equilibrium centrifugation | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
| Meleagris gallopavo | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Oryctolagus cuniculus | - |
| brain | - |
Oryctolagus cuniculus | - |
| brain | mammals, calcineurin, i.e. phosphatase 2 B | Mammalia | - |
| additional information | - |
Mammalia | - |
| additional information | - |
Oryctolagus cuniculus | - |
| nerve | calcineurin, i.e. phosphatase 2B | Mammalia | - |
| smooth muscle | - |
Meleagris gallopavo | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mammalia |
| additional information | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphohistone + H2O | - |
Meleagris gallopavo | histone + phosphate | - |
? | |
| phosphohistone + H2O | - |
Oryctolagus cuniculus | histone + phosphate | - |
? | |
| phosphomyosin light chain + H2O | - |
Meleagris gallopavo | myosin light chain + phosphate | - |
? | |
| phosphomyosin light chain + H2O | - |
Oryctolagus cuniculus | myosin light chain + phosphate | - |
? | |
| phosphophosphorylase kinase + H2O | specific for alpha-subunit | Oryctolagus cuniculus | phosphorylase kinase + phosphate | - |
? | |
| phosphoprotamine + H2O | - |
Oryctolagus cuniculus | protamine + phosphate | - |
? | |
| phosphoproteins + H2O | - |
Meleagris gallopavo | proteins + phosphate | - |
? | |
| phosphoproteins + H2O | - |
Mammalia | proteins + phosphate | - |
? | |
| phosphoproteins + H2O | - |
Oryctolagus cuniculus | proteins + phosphate | - |
? | |
| phosphorylase a + H2O | - |
Meleagris gallopavo | phosphorylase b + phosphate | - |
? | |
| phosphorylase a + H2O | - |
Oryctolagus cuniculus | phosphorylase b + phosphate | - |
? | |
| phosphorylated brain proteins + H2O | e.g. DARPP-32, G-substrate, both phosphorylated at threonine, similar amino acid sequences and phosphorylation sites, protein K-F. | Oryctolagus cuniculus | brain proteins + phosphate | - |
? | |
| phosphorylated inhibitor-1 + H2O | - |
Oryctolagus cuniculus | inhibitor-1 + phosphate | - |
? | |
| phosphorylated inhibitor-2 + H2O | - |
Oryctolagus cuniculus | inhibitor-2 + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Meleagris gallopavo |
| dimer | - |
Mammalia |
| tetramer | AB'C2, phosphatase 2A0, A: 60000, B: 54000, C: 36000, rabbit, SDS-PAGE | Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | activation, dependent on Ca2+ | Mammalia | |
| Calmodulin | activation, dependent on Ca2+ | Oryctolagus cuniculus | |
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