Literature summary for 3.1.3.11 extracted from

Li, K.; Ying, M.; Feng, D.; Du, J.; Chen, S.; Dan, B.; Wang, C.; Wang, Y.
Fructose-1,6-bisphosphatase is a novel regulator of Wnt/beta-catenin pathway in breast cancer (2016), Biomed. Pharmacother., 84, 1144-1149 .

Search for more literature for 3.1.3.11

Application

Application	Comment	Organism
diagnostics	upregulated FBP1 predicts a good prognosis in breast cancer, while downregulated FBP1 expression is associated with poor clinical outcome	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene FBP1, quantitative real-time PCR enzyme expression analysis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	genetic silencing of fructose-1,6-bisphosphatase (FBP1), FBP1 downregulation enhances the activity of Wnt/beta-catenin pathway and increases the level of its downstream targets, including c-Myc and MMP7	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-fructose 1,6-bisphosphate + H2O	Homo sapiens	-	D-fructose 6-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00757	-	-
Homo sapiens	P09467	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	FBP1 is commonly upregulated in tumor tissues compared with non-tumor tissues regardless of histological type. Enzyme expression profiles of breast cancer cells reveals that cells exhibiting high expression of FBP1 have a lower activity of Wnt/beta-catenin pathway	Homo sapiens	-
breast cancer cell	FBP1 is commonly upregulated in tumor tissues compared with non-tumor tissues regardless of histological type	Homo sapiens	-
BT-474 cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 1,6-bisphosphate + H2O	-	Homo sapiens	D-fructose 6-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
FBP1	-	Homo sapiens
fructose-1,6-bisphosphatase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is up-regulated in tumor tissues compared with non-tumor tissues regardless of histological type	up

General Information

General Information	Comment	Organism
malfunction	genetic silencing of enzyme fructose-1,6-bisphosphatase (FBP1) reduces aerobic glycolysis and the malignant potential of breast cancer cells. FBP1 down-regulation enhances the activity of Wnt/b-Catenin pathway and increases the level of its downstream targets, including c-Myc and MMP7	Homo sapiens
metabolism	the enzyme (FBP1) is rate-limiting in gluconeogenes. Its downregulation enhances the activity of Wnt/beta-catenin pathway and increases the level of its downstream targets, including c-Myc and MMP7. Elevated fructose-1,6-bisphosphatase is a critical modulator in breast cancer progression by altering glucose metabolism and the activity of Wnt/beta-Catenin pathway. The enzyme is a tumor suppressor that is frequently down-regulated in cancers, especially breast cancer. Lower FBP1 expression is associated with poor clinical outcome. Up-regulated FBP1 predicts a good prognosis in breast cancer	Homo sapiens
physiological function	fructose-1,6-bisphosphatase (FBP1), the rate-limiting enzyme in gluconeogenesis, is a tumor suppressor, especially of breast cancer. The enzyme is commonly upregulated in tumor tissues compared with non-tumor tissues regardless of histological type, and lower FBP1 expression is associated with poor clinical outcome. Genetic silencing of FBP1 reduces aerobic glycolysis and the malignant potential of breast cancer cells. Elevated FBP1 is a critical modulator in breast cancer progression by altering glucose metabolism and the activity of Wnt/ beta-catenin pathway. Mechanism by which FBP1 inhibits tumor progression in breast cancer, overview. The inhibitory effect of FBP1 in glycolysis might be mediated by downregulation of c-Myc	Homo sapiens

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Release 2023.1 (January 2023)