Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-[2-(5-N,N'-bis((S)-1-(1-ethoxycarbonyl)ethyl)phosphonoamido)furanyl]-5-isobutylthiazole | optimization of the diamide prodrugs of phosphonic acid leads to the identification of a new diamide, the first reported orally efficacious FBPase inhibitor | Homo sapiens | |
2-amino-4-[2-(5-phosphono)furanyl]-5-ethoxycarbonylthiazole | potent FBPase inhibitor | Homo sapiens | |
2-amino-4-[2-(5-phosphono)furanyl]-5-ethoxycarbonylthiazole | potent FBPase inhibitor: when administerd intravenously it lowers plasma glucose levels in 18 h fasted normal Sprague-Dawley rats above 50% at doses below 10 mg/kg | Rattus norvegicus | |
2-amino-4-[2-(5-phosphono)furanyl]-5-isobutylthiazole | potent FBPase inhibitor | Homo sapiens | |
2-amino-4-[2-(5-phosphono)furanyl]-5-isobutylthiazole | potent FBPase inhibitor: when administerd intravenously it lowers plasma glucose levels in 18 h fasted normal Sprague-Dawley rats above 50% at doses below 10 mg/kg | Rattus norvegicus | |
2-amino-4-[2-(5-phosphono)furanyl]-5-phenylthiazole | potent FBPase inhibitor | Homo sapiens | |
2-amino-4-[2-(5-phosphono)furanyl]-5-phenylthiazole | potent FBPase inhibitor: when administerd intravenously it lowers plasma glucose levels in 18 h fasted normal Sprague-Dawley rats above 50% at doses below 10 mg/kg | Rattus norvegicus | |
2-amino-4-[2-(5-phosphono)furanyl]-5-propylsulfanylthiazole | potent FBPase inhibitor | Homo sapiens | |
2-amino-4-[2-(5-phosphono)furanyl]-5-propylsulfanylthiazole | potent FBPase inhibitor: when administerd intravenously it lowers plasma glucose levels in 18 h fasted normal Sprague-Dawley rats above 50% at doses below 10 mg/kg | Rattus norvegicus | |
2-amino-5-methylsulfanyl-4-[2-(5-diethylphosphono)furanyl]thiazole | potent FBPase inhibitor | Homo sapiens | |
2-amino-5-methylsulfanyl-4-[2-(5-diethylphosphono)furanyl]thiazole | potent FBPase inhibitor: when administerd intravenously it lowers plasma glucose levels in 18 h fasted normal Sprague-Dawley rats above 50% at doses below 10 mg/kg | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
FBPase | - |
Homo sapiens |
FBPase | - |
Rattus norvegicus |
fructose 1,6-bisphosphatase | - |
Homo sapiens |
fructose 1,6-bisphosphatase | - |
Rattus norvegicus |