Application | Comment | Organism |
---|---|---|
medicine | upregulation of FBPase in pancreatic islet beta-cells, as occurs in states of lipid oversupply and type 2 diabetes, contributes to insulin secretory dysfunction | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | transgenic mouse lines overexpressing huFBPase gene specifically in pancreatic islet beta-cells are generated to determine whether a specific increase in islet beta-cell FBPase can result in reduced glucose-mediated insulin secretion. FBPase transgenic mice show reduced insulin secretion in response to an intravenous glucose bolus. Pancreatic beta-cell lines (MIN6) stably overexpressing huFBPase show a decreased cell proliferation rate and significantly depressed glucose-induced insulin secretion. These defects are associated with a decrease in the rate of glucose utilization, resulting in reduced cellular ATP levels | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
fructose 1,6-bisphosphatase | - |
Homo sapiens |
huFBPase | - |
Homo sapiens |