Literature summary for 3.1.3.11 extracted from

van Poelje, P.D.; Dang, Q.; Erion, M.D.
Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes (2007), Curr. Opin. Drug Discov. Devel., 10, 430-437.

Search for more literature for 3.1.3.11

Application

Application	Comment	Organism
medicine	fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide	non-competitive	Homo sapiens
2-(2-aminoethyl)-6,7-diethoxy-N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]quinazolin-4-amine	uncompetitive	Homo sapiens
2-[(3S,11aS)-3-(4-hydroxybenzyl)-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-N-[2-(4-hydroxyphenyl)ethyl]pentanamide	uncompetitive	Homo sapiens
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid	non-competitive	Homo sapiens
diphenyl [5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonate	non-competitive	Homo sapiens
ethyl (2S,6S)-4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide	-	Homo sapiens
N,N'-bis(6,7-diethoxy-2,3-dihydro-1H-cyclopenta[b]quinolin-9-yl)pentane-1,5-diamine	uncompetitive	Homo sapiens
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide	non-competitive	Homo sapiens
N-[6-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide	non-competitive	Homo sapiens
[(2R,3S,4R,5R)-5-[4-(aminocarbonyl)-1H-imidazol-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate	-	Homo sapiens
[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid	non-competitive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000016	-	non-competitive	Homo sapiens	[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
0.00022	-	uncompetitive	Homo sapiens	2-(2-aminoethyl)-6,7-diethoxy-N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]quinazolin-4-amine
0.00057	-	non-competitive	Homo sapiens	N-[6-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
0.00187	-	uncompetitive	Homo sapiens	2-[(3S,11aS)-3-(4-hydroxybenzyl)-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-N-[2-(4-hydroxyphenyl)ethyl]pentanamide
0.0025	-	non-competitive	Homo sapiens	N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
0.0025	-	non-competitive	Homo sapiens	3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
0.0026	-	uncompetitive	Homo sapiens	N,N'-bis(6,7-diethoxy-2,3-dihydro-1H-cyclopenta[b]quinolin-9-yl)pentane-1,5-diamine
0.0034	-	non-competitive	Homo sapiens	2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
0.012	-	-	Homo sapiens	[(2R,3S,4R,5R)-5-[4-(aminocarbonyl)-1H-imidazol-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate

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Release 2023.1 (January 2023)