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Literature summary for 3.1.3.108 extracted from

  • Laothamatas, I.; Gao, P.; Wickramaratne, A.; Quintanilla, C.G.; Dino, A.; Khan, C.A.; Liou, J.; Green, C.B.
    Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response (2020), Proc. Natl. Acad. Sci. USA, 117, 993-999 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.108

Protein Variants

Protein Variants Comment Organism
E193A catalytically inactive mutant Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.098
-
 NADPH 22°C, pH not specified in the publication Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm the cytoplasmic form of nocturnin is constitutively expressed and associates externally with membranes of other organelles, including the endoplasmic reticulum, via N-terminal glycine myristoylation Mus musculus 5737
-
mitochondrion mitochondrial form of nocturnin possesses high-amplitude circadian rhythmicity with peak expression level during the early dark phase Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADP+ + H2O Mus musculus
-
 NAD+ + phosphate
-
 ?
NADPH + H2O Mus musculus
-
 NADH + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O35710
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADP+ + H2O
-
 Mus musculus NAD+ + phosphate
-
 ?
NADPH + H2O
-
 Mus musculus NADH + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
NADP(H) phosphatase
-
 Mus musculus
NADPH 2'-phosphatase
-
 Mus musculus
Noc
-
 Mus musculus
NOCT
-
 Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
15.6
-
 NADPH 22°C, pH not specified in the publication Mus musculus

Expression

Organism Comment Expression
Mus musculus mitochondrial form of nocturnin possesses high-amplitude circadian rhythmicity with peak expression level during the early dark phase down
Mus musculus mitochondrial form of nocturnin possesses high-amplitude circadian rhythmicity with peak expression level during the early dark phase up

General Information

General Information Comment Organism
physiological function the enzyme is a direct regulator of oxidative stress response through its NADPH 2' phosphatase activity. It regulates local intracellular concentrations of NADP(H) in a manner that changes over the course of the day Mus musculus