Literature summary for 3.1.3.108 extracted from

Godwin, A.; Kojima, S.; Green, C.; Wilusz, J.
Kiss your tail goodbye The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology (2013), Biochim. Biophys. Acta, 1829, 571-579 .

Search for more literature for 3.1.3.108

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O35710	-	-

Expression

Organism	Comment	Expression
Mus musculus	nocturin deadenylase shows rhythmic expression under circadian control. It is rapidly induced in response to serum shock, LPS and other stimuli	up

General Information

General Information	Comment	Organism
malfunction	Noc knock-out (Noc-/-) mice exhibit no obvious abnormalities in development or reproduction, however, they exhibit striking metabolic phenotypes when fed a High-Fat Diet (HFD). This diet causes wild-type mice to become obese, but the Noc-/- mice remain lean although they do not exhibit increased activity or reduced food intake	Mus musculus
physiological function	PARN, nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appears to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. Nocturnin functions in adipogenesis and lipid metabolism	Mus musculus

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Release 2023.1 (January 2023)