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Literature summary for 3.1.3.108 extracted from
- Structure and function of NAD kinase and NADP phosphatase key enzymes that regulate the intracellular balance of NAD(H) and NADP(H) (2008), Biosci. Biotechnol. Biochem., 72, 919-930 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
NADP+ | pH and temperature not specified in the publication | Archaeoglobus fulgidus |  |
| 0.18 | - |
NADP+ | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 0.3 | - |
NADPH | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 0.36 | - |
NADPH | pH and temperature not specified in the publication | Archaeoglobus fulgidus | |
| 0.54 | - |
NADP+ | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 0.77 | - |
NADPH | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADP+ + H2O | Archaeoglobus fulgidus | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | Methanocaldococcus jannaschii | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | Archaeoglobus fulgidus ATCC 49558 | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | Methanocaldococcus jannaschii ATCC 43067 | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NAD+ + phosphate | - |
? | |
| NADPH + H2O | Archaeoglobus fulgidus | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NADH + phosphate | - |
? | |
| NADPH + H2O | Methanocaldococcus jannaschii | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NADH + phosphate | - |
? | |
| NADPH + H2O | Archaeoglobus fulgidus ATCC 49558 | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NADH + phosphate | - |
? | |
| NADPH + H2O | Methanocaldococcus jannaschii ATCC 43067 | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | NADH + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Archaeoglobus fulgidus | O30298 | cf. EC 3.1.3.11, EC 3.1.3.25 | - |
| Archaeoglobus fulgidus ATCC 49558 | O30298 | cf. EC 3.1.3.11, EC 3.1.3.25 | - |
| Methanocaldococcus jannaschii | Q57573 | cf. EC 3.1.3.11 | - |
| Methanocaldococcus jannaschii | Q58327 | cf. EC 2.7.1.23 | - |
| Methanocaldococcus jannaschii ATCC 43067 | Q57573 | cf. EC 3.1.3.11 | - |
| Methanocaldococcus jannaschii ATCC 43067 | Q58327 | cf. EC 2.7.1.23 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADP+ + H2O | - |
Archaeoglobus fulgidus | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | - |
Methanocaldococcus jannaschii | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Archaeoglobus fulgidus | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Methanocaldococcus jannaschii | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | - |
Archaeoglobus fulgidus ATCC 49558 | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Archaeoglobus fulgidus ATCC 49558 | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | - |
Methanocaldococcus jannaschii ATCC 43067 | NAD+ + phosphate | - |
? | |
| NADP+ + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Methanocaldococcus jannaschii ATCC 43067 | NAD+ + phosphate | - |
? | |
| NADPH + H2O | - |
Archaeoglobus fulgidus | NADH + phosphate | - |
? | |
| NADPH + H2O | - |
Methanocaldococcus jannaschii | NADH + phosphate | - |
? | |
| NADPH + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Archaeoglobus fulgidus | NADH + phosphate | - |
? | |
| NADPH + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Methanocaldococcus jannaschii | NADH + phosphate | - |
? | |
| NADPH + H2O | - |
Archaeoglobus fulgidus ATCC 49558 | NADH + phosphate | - |
? | |
| NADPH + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Archaeoglobus fulgidus ATCC 49558 | NADH + phosphate | - |
? | |
| NADPH + H2O | - |
Methanocaldococcus jannaschii ATCC 43067 | NADH + phosphate | - |
? | |
| NADPH + H2O | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Methanocaldococcus jannaschii ATCC 43067 | NADH + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AF2372 | - |
Archaeoglobus fulgidus |
| MJ0109 | - |
Methanocaldococcus jannaschii |
| MJ0917 | - |
Methanocaldococcus jannaschii |
| NADP phosphatase | - |
Archaeoglobus fulgidus |
| NADP phosphatase | - |
Methanocaldococcus jannaschii |
| NADPase | - |
Archaeoglobus fulgidus |
| NADPase | - |
Methanocaldococcus jannaschii |
| NADPHase | - |
Archaeoglobus fulgidus |
| NADPHase | - |
Methanocaldococcus jannaschii |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5 | - |
NADP+ | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 6.9 | - |
NADPH | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 26.3 | - |
NADP+ | pH and temperature not specified in the publication | Archaeoglobus fulgidus | |
| 40.3 | - |
NADPH | pH and temperature not specified in the publication | Archaeoglobus fulgidus | |
| 212 | - |
NADP+ | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 236 | - |
NADPH | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Archaeoglobus fulgidus |
| physiological function | the enzyme regulates the intracellular balance of NAD(H) and NADP(H) | Methanocaldococcus jannaschii |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 8.9 | - |
NADPH | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 9.2 | - |
NADP+ | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 56.8 | - |
NADP+ | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 63.1 | - |
NADPH | pH and temperature not specified in the publication | Methanocaldococcus jannaschii | |
| 113 | - |
NADPH | pH and temperature not specified in the publication | Archaeoglobus fulgidus | |
| 188 | - |
NADP+ | pH and temperature not specified in the publication | Archaeoglobus fulgidus | |
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