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Literature summary for 3.1.3.106 extracted from

  • Chryplewicz, A.; Tienda, S.M.; Nahotko, D.A.; Peters, P.N.; Lengyel, E.; Eckert, M.A.
    Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6 (2019), Sci. Rep., 9, 5195 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine highly expressed in normal fallopian tube epithelium, ACP6 expression is significantly reduced in ovarian cancer tumors and early in situ lesions. Downregulation of ACP6 in ovarian cancer cells is necessary and sufficient to support high-grade serous ovarian cancer proliferation, adhesion, migration, and invasion Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NPH0
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium fallopian tube epithelium Homo sapiens
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General Information

General Information Comment Organism
physiological function gain-of-function mutations in TP53 downregulate the lysophosphatidic acid phosphatase type 6 (ACP6), leading to upregulation of focal adhesion signaling in an lysophosphatidic acid-dependent manner. Highly expressed in normal fallopian tube epithelium, ACP6 expression is significantly reduced in ovarian cancer tumors and early in situ lesions Homo sapiens