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Literature summary for 3.1.3.106 extracted from

  • Burgdorf, C.; Haensel, L.; Heidbreder, M.; Joehren, O.; Schuette, F.; Schunkert, H.; Kurz, T.
    Suppression of cardiac phosphatidate phosphohydrolase 1 activity and lipin mRNA expression in Zucker diabetic fatty rats and humans with type 2 diabetes mellitus (2009), Biochem. Biophys. Res. Commun., 390, 165-170.
    View publication on PubMed
Search for more literature for 3.1.3.106

Activating Compound

Activating Compound Comment Organism Structure
Insulin insulin therapy increases both PAP1 activity and lipin mRNA expression in diabetic patients Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart presence of lipin-1 and lipin-3, lipin-2 is absent. Marked differences in cardiac distribution of PAP1 Rattus norvegicus
-
left ventricle
-
 Rattus norvegicus
-
additional information atrial tissue Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C Homo sapiens
-80°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O
-
 Homo sapiens 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate
-
 ?
1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycero-3-phosphate + H2O
-
 Rattus norvegicus 1-hexanoyl-2-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-glycerol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
lipin
-
 Homo sapiens
lipin
-
 Rattus norvegicus
lipin-1
-
 Homo sapiens
lipin-1
-
 Rattus norvegicus
lipin-3
-
 Homo sapiens
lipin-3
-
 Rattus norvegicus
PAP1
-
 Homo sapiens
PAP1
-
 Rattus norvegicus
phosphatidate phosphohydrolase 1
-
 Homo sapiens
phosphatidate phosphohydrolase 1
-
 Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens atrial lipin-1 and lipin-3 mRNA expression in diabetic patients is 50% and 59% lower as in non-diabetic patients, respectively down
Rattus norvegicus PAP1 activity is highly related with cardiac lipin-1 and lipin-3 mRNA expression in Zucker diabetic fatty rats additional information
Homo sapiens insulin therapy increases both PAP1 activity and lipin mRNA expression in diabetic patients up
Rattus norvegicus left ventricular lipin-1 and lipin-3 expression is 7- to 27fold higher than respective atrial mRNA expression n Zucker diabetic fatty rats up

General Information

General Information Comment Organism
malfunction suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart Homo sapiens
malfunction suppression of cardiac PAP1 activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart Rattus norvegicus
physiological function atrial tissue displays PAP1 activity that is 33% lower in those having type 2 diabetes mellitus than in non-diabetic controls Homo sapiens
physiological function compared to non-diabetic littermates, left ventricular PAP1 activity is 29% lower in 8-months-old Zucker diabetic fatty rats. Left ventricular PAP1 activities are 2.1fold (diabetic fatty rats) and 3.6fold (non-diabetic rats) higher than the respective atrial activities Rattus norvegicus