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Literature summary for 3.1.3.1 extracted from

  • Pettengill, M.; Robson, S.; Tresenriter, M.; Millan, J.L.; Usheva, A.; Bingham, T.; Belderbos, M.; Bergelson, I.; Burl, S.; Kampmann, B.; Gelinas, L.; Kollmann, T.; Bont, L.; Levy, O.
    Soluble ecto-5-nucleotidase (5-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine (2013), J. Biol. Chem., 288, 27315-27326.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in neonatal blood plasma, soluble 5'-nucleotidase and alkaline phosphatase mediate conversion of AMP to adenosine, whereas soluble adenosine deaminase catabolizes adenosine to inosine. Newborn blood plasma demonstrates substantially higher adenosine-generating 5'-nucleotidase and alkaline phosphatase activity and lower metabolizing adenosine deaminase activity than adult plasma. Abundant alkaline phosphatase expressed on the surface of circulating neonatal neutrophils is the dominant AMPase on these cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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General Information

General Information Comment Organism
physiological function in neonatal blood plasma, soluble 5'-nucleotidase and alkaline phosphatase mediate conversion of AMP to adenosine, whereas soluble adenosine deaminase catabolizes adenosine to inosine. Newborn blood plasma demonstrates substantially higher adenosine-generating 5'-nucleotidase and alkaline phosphatase activity and lower metabolizing adenosine deaminase activity than adult plasma. Abundant alkaline phosphatase expressed on the surface of circulating neonatal neutrophils is the dominant AMPase on these cells Homo sapiens