Literature summary for 3.1.3.1 extracted from

Dahl, R.; Sergienko, E.A.; Su, Y.; Mostofi, Y.S.; Yang, L.; Simao, A.M.; Narisawa, S.; Brown, B.; Mangravita-Novo, A.; Vicchiarelli, M.; Smith, L.H.; ONeill, W.C.; Millan, J.L.; Cosford, N.D.
Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) (2009), J. Med. Chem., 52, 6919-6925.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1,4-dimethoxy-2-methylbenzene	-	Homo sapiens
1-chloro-4-ethoxy-2-methylbenzene	-	Homo sapiens
1-chloro-4-methoxy-2-methylbenzene	-	Homo sapiens
1-fluoro-4-methoxybenzene	-	Homo sapiens
2,5-dimethoxy-N-(pyridin-3-yl)benzenesulfonamide	-	Homo sapiens
2,5-dimethoxy-N-(quinolin-3-yl)benzenesulfonamide	-	Homo sapiens
2-chloro-1,4-dimethoxybenzene	-	Homo sapiens
2-ethoxy-5-methyl-N-(pyridin-3-yl)benzenesulfonamide	-	Homo sapiens
2-methoxy-4-nitro-N-(pyridin-3-yl)benzenesulfonamide	-	Homo sapiens
2-methoxy-4-nitro-N-(quinolin-3-yl)benzenesulfonamide	-	Homo sapiens
2-methoxy-5-methyl-N-(pyridin-3-yl)benzenesulfonamide	-	Homo sapiens
2-methoxy-5-methyl-N-(quinolin-3-yl)benzenesulfonamide	-	Homo sapiens
4-bromo-2,5-dimethoxy-N-(pyridin-3-yl)benzenesulfonamide	-	Homo sapiens
4-methoxy-1,2-dimethylbenzene	-	Homo sapiens
5-bromo-2-methoxy-N-(quinolin-3-yl)benzenesulfonamide	-	Homo sapiens
5-chloro-2-ethoxy-N-(pyridin-3-yl)benzenesulfonamide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenyl phosphate + H2O	CDP-star	Homo sapiens	2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenol + phosphate	-	?
4-nitrophenyl phosphate + H2O	-	Homo sapiens	4-nitrophenol + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
tissue-nonspecific alkaline phosphatase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00012	-	-	Homo sapiens	5-bromo-2-methoxy-N-(quinolin-3-yl)benzenesulfonamide
0.00019	-	-	Homo sapiens	2,5-dimethoxy-N-(quinolin-3-yl)benzenesulfonamide
0.00051	-	-	Homo sapiens	1-chloro-4-methoxy-2-methylbenzene
0.00054	-	-	Homo sapiens	5-chloro-2-ethoxy-N-(pyridin-3-yl)benzenesulfonamide
0.00065	-	-	Homo sapiens	2-methoxy-5-methyl-N-(quinolin-3-yl)benzenesulfonamide
0.00069	-	-	Homo sapiens	1-chloro-4-ethoxy-2-methylbenzene
0.00074	-	-	Homo sapiens	2-methoxy-4-nitro-N-(quinolin-3-yl)benzenesulfonamide
0.00106	-	-	Homo sapiens	2,5-dimethoxy-N-(pyridin-3-yl)benzenesulfonamide
0.00113	-	-	Homo sapiens	2-chloro-1,4-dimethoxybenzene
0.00113	-	-	Homo sapiens	2-ethoxy-5-methyl-N-(pyridin-3-yl)benzenesulfonamide
0.00129	-	-	Homo sapiens	1-fluoro-4-methoxybenzene
0.00149	-	-	Homo sapiens	1,4-dimethoxy-2-methylbenzene
0.00155	-	-	Homo sapiens	4-bromo-2,5-dimethoxy-N-(pyridin-3-yl)benzenesulfonamide
0.00168	-	-	Homo sapiens	4-methoxy-1,2-dimethylbenzene
0.00185	-	-	Homo sapiens	2-methoxy-5-methyl-N-(pyridin-3-yl)benzenesulfonamide
0.00316	-	-	Homo sapiens	2-methoxy-4-nitro-N-(pyridin-3-yl)benzenesulfonamide

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Release 2023.1 (January 2023)