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Literature summary for 3.1.3.1 extracted from
- In vitro modulation of alkaline phosphatase activity of Saccharomyces cerevisiae grown in low or high phosphate medium (2008), Braz. J. Med. Biol. Res., 41, 41-46.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| beta-estradiol | concentration dependent activation of alkaline phosphatase grown in low phosphate medium | Saccharomyces cerevisiae |  |
| cholesterol | concentration dependent activation of alkaline phosphatase grown in low phosphate medium | Saccharomyces cerevisiae | |
| L-homoarginine | 5 mM, activation of alkaline phosphatase grown in high phosphate medium to 186% of the control value, alkaline phosphatase grown in low phosphate medium is activated to 166% of control | Saccharomyces cerevisiae | |
| L-Leu | 5 mM, activation of alkaline phosphatase grown in high phosphate medium to 155% of the control value | Saccharomyces cerevisiae | |
| L-Phe | 5 mM, activation of alkaline phosphatase grown in high phosphate medium to 168% of the control value | Saccharomyces cerevisiae | |
| levamisole | 1 mM, activation of alkaline phosphatase grown in high phosphate medium to 122% of the control value | Saccharomyces cerevisiae | |
| progesterone | concentration dependent activation of alkaline phosphatase grown in low phosphate medium | Saccharomyces cerevisiae | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| corticosterone | 5 mM, 90% inhibition of alkaline phosphatase grown in high phosphate medium, no effect is observed with alkaline phosphatase grown in low phosphate medium | Saccharomyces cerevisiae | |
| vanadate | 1 mM, 22% inhibition of alkaline phosphatase grown in high phosphate medium | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | the product of the PHO8 gene is repressible by phosphate in the medium | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the product of the PHO8 gene is repressible by phosphate in the medium | Saccharomyces cerevisiae | ? | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Saccharomyces cerevisiae | p-nitrophenol + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PHO13 | - |
Saccharomyces cerevisiae |
| PHO8 | - |
Saccharomyces cerevisiae |
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