Literature summary for 3.1.26.5 extracted from

Niland, C.N.; Zhao, J.; Lin, H.C.; Anderson, D.R.; Jankowsky, E.; Harris, M.E.
Determination of the specificity landscape for ribonuclease P processing of precursor tRNA 5 leader sequences (2016), ACS Chem. Biol., 11, 2285-2292 .

Search for more literature for 3.1.26.5

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pre-tRNA + H2O	the identity of N(-2) and N(-3) relative to the cleavage site at N(1) primarily control alternative substrate selection and act at the level of association not the cleavage step. As a consequence, the specificity for N(-1), which contacts the active site and contributes to catalysis, is suppressed	Escherichia coli	mature tRNA + 5'-terminal oligonucleotide	-	?

Synonyms

Synonyms	Comment	Organism
RNase P	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	maturation of tRNA depends on a single endonuclease, ribonuclease P, to remove highly variable 5' leader sequences from precursor tRNA transcripts	Escherichia coli

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)