Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.26.5 extracted from

  • Zwieb, C.; Nakao, Y.; Nakashima, T.; Takagi, H.; Goda, S.; Andersen, E.; Kakuta, Y.; Kimura, M.
    Structural modeling of RNase P RNA of the hyperthermophilic archaeon Pyrococcus horikoshii OT3 (2011), Biochem. Biophys. Res. Commun., 414, 517-522 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
protein PhoPop5 the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30 Pyrococcus horikoshii
protein PhoRpp21 the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30 Pyrococcus horikoshii
protein PhoRpp29 the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30 Pyrococcus horikoshii
protein PhoRpp30 the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30 Pyrococcus horikoshii
protein PhoRpp38 the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30 Pyrococcus horikoshii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pre-tRNA + H2O Pyrococcus horikoshii
-
mature tRNA + 5'-terminal oligonucleotide
-
?

Organism

Organism UniProt Comment Textmining
Pyrococcus horikoshii O59425 and O59150 and O59543 and O59248 and P62009 O59425: ribonuclease P protein component 1 (PhoRpp29), O59150: ribonuclease P protein component 2 (PhoPop5), O59543: ribonuclease P protein component 3 (PhoRpp30), O59248: ribonuclease P protein component 4 (RPP21), 50S ribosomal protein L7Ae (PhoRpp38). RNase P consists of a catalytic RNase P RNA (PhopRNA) and five protein cofactors designated PhoPop5, PhoRpp21, PhoRpp29, PhoRpp30, and PhoRpp38
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pre-tRNA + H2O
-
Pyrococcus horikoshii mature tRNA + 5'-terminal oligonucleotide
-
?

Synonyms

Synonyms Comment Organism
RNase P
-
Pyrococcus horikoshii

General Information

General Information Comment Organism
additional information the secondary structure of RNase P RNA is reexamined using stringent comparative tools to arrive at phylogenetically supported model. The model structure shows an essentially flat disk with 16 tightly packed helices and a conserved face suitable for the binding of pre-tRNA. The low resolution model derived from small-angle X-ray scattering and the comparative 3-D model have similar overall shapes. The 3-D model provides a framework for a better understanding of structure-function relationships of this multifaceted primordial ribozyme Pyrococcus horikoshii