Application | Comment | Organism |
---|---|---|
biotechnology | RNA-mediated RNA cleavage events are being increasingly exploited to disrupt RNA function, an important objective in post-genomic biology. RNase P, a ribonucleoprotein enzyme that catalyzes the removal of 5'-leaders from precursor tRNAs, has previously been utilized for sequence-specific cleavage of cellular RNAs | Methanothermobacter thermautotrophicus |
biotechnology | RNA-mediated RNA cleavage events are being increasingly exploited to disrupt RNA function, an important objective in post-genomic biology. RNase P, a ribonucleoprotein enzyme that catalyzes the removal of 5'-leaders from precursor tRNAs, has previously been utilized for sequence-specific cleavage of cellular RNAs | Pyrococcus furiosus |
biotechnology | RNA-mediated RNA cleavage events are being increasingly exploited to disrupt RNA function, an important objective in post-genomic biology. RNase P, a ribonucleoprotein enzyme that catalyzes the removal of 5'-leaders from precursor tRNAs, has previously been utilized for sequence-specific cleavage of cellular RNAs | Methanocaldococcus jannaschii |
biotechnology | RNA-mediated RNA cleavage events are being increasingly exploited to disrupt RNA function, an important objective in post-genomic biology. RNase P, a ribonucleoprotein enzyme that catalyzes the removal of 5'-leaders from precursor tRNAs, has previously been utilized for sequence-specific cleavage of cellular RNAs | Methanococcus maripaludis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanocaldococcus jannaschii | - |
- |
- |
Methanococcus maripaludis | - |
- |
- |
Methanothermobacter thermautotrophicus | - |
- |
- |
Pyrococcus furiosus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | an external guide sequence, EGS, RNA base-paired to a target RNA makes the latter a substrate for endogenous RNase P by rendering the bipartite target RNA-EGS complex a precursor tRNA structural mimic. RNase P holoenzymes recognize and cleave such substrate-EGS complexes. The external guide sequences engage in multiple rounds of substrate recognition while assisting archaeal RNase P-mediated cleavage of a target RNA in vitro | Methanothermobacter thermautotrophicus | ? | - |
? | |
additional information | an external guide sequence, EGS, RNA base-paired to a target RNA makes the latter a substrate for endogenous RNase P by rendering the bipartite target RNA-EGS complex a precursor tRNA structural mimic. RNase P holoenzymes recognize and cleave such substrate-EGS complexes. The external guide sequences engage in multiple rounds of substrate recognition while assisting archaeal RNase P-mediated cleavage of a target RNA in vitro | Pyrococcus furiosus | ? | - |
? | |
additional information | an external guide sequence, EGS, RNA base-paired to a target RNA makes the latter a substrate for endogenous RNase P by rendering the bipartite target RNA-EGS complex a precursor tRNA structural mimic. RNase P holoenzymes recognize and cleave such substrate-EGS complexes. The external guide sequences engage in multiple rounds of substrate recognition while assisting archaeal RNase P-mediated cleavage of a target RNA in vitro | Methanocaldococcus jannaschii | ? | - |
? | |
additional information | an external guide sequence, EGS, RNA base-paired to a target RNA makes the latter a substrate for endogenous RNase P by rendering the bipartite target RNA-EGS complex a precursor tRNA structural mimic. RNase P holoenzymes recognize and cleave such substrate-EGS complexes. The external guide sequences engage in multiple rounds of substrate recognition while assisting archaeal RNase P-mediated cleavage of a target RNA in vitro | Methanococcus maripaludis | ? | - |
? | |
pre-tRNA + H2O | RNase P holoenzymes, reconstituted in vitro | Methanothermobacter thermautotrophicus | tRNA + 5' leader of tRNA | - |
? | |
pre-tRNA + H2O | RNase P holoenzymes, reconstituted in vitro | Pyrococcus furiosus | tRNA + 5' leader of tRNA | - |
? | |
pre-tRNA + H2O | RNase P holoenzymes, reconstituted in vitro | Methanocaldococcus jannaschii | tRNA + 5' leader of tRNA | - |
? | |
pre-tRNA + H2O | RNase P holoenzymes, reconstituted in vitro | Methanococcus maripaludis | tRNA + 5' leader of tRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNase P | - |
Methanothermobacter thermautotrophicus |
RNase P | - |
Pyrococcus furiosus |
RNase P | - |
Methanocaldococcus jannaschii |
RNase P | - |
Methanococcus maripaludis |