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Literature summary for 3.1.26.5 extracted from

  • Krasilnikov, A.S.; Yang, X.; Pan, T.; Mondragon, A.
    Crystal structure of the specificity domain of ribonuclease P (2003), Nature, 421, 760-764.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystallization of the S domain of the RNA subunit, X-ray diffraction structure determination and analysis at 3.15 A resolution, structure modeling Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacillus subtilis substrate specificity is determined by the enzymes' RNA fold, the structure of the specificity domain of the RNA subunit provides the basis of understanding the structurs of other bacterial ribozyme molecules because all bacterial S domains havea common core that comprises stems P7-P11 plus J11/12-J12/11 module, overview ?
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tRNA precursor + H2O Bacillus subtilis tRNA processing mature tRNA + 5'-oligonucleotide
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?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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the B-type enzyme is a ribonucleoprotein
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity is determined by the enzymes' RNA fold, the structure of the specificity domain of the RNA subunit provides the basis of understanding the structurs of other bacterial ribozyme molecules because all bacterial S domains havea common core that comprises stems P7-P11 plus J11/12-J12/11 module, overview Bacillus subtilis ?
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?
additional information the RNA subunit can cleave tRNA substrate in absence of the protein subunit Bacillus subtilis ?
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tRNA precursor + H2O tRNA processing Bacillus subtilis mature tRNA + 5'-oligonucleotide
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?
tRNA precursor + H2O cleavage of 5'-terminal oligonucleotide Bacillus subtilis mature tRNA + 5'-oligonucleotide generates 5'-phosphate,3'-hydroxyl-product ?

Subunits

Subunits Comment Organism
More enzyme is composed of 1 RNA subunit of 350-450 nucleotides and 1 protein subunit of about 120 amino acids, the RNA subunit is divided into the specificity and the catalytic domain, i.e. S domain, comprising nucleotides 86-239, and C domain, comprising the rest of the molecule, overall and secondary structure, modeling Bacillus subtilis

Synonyms

Synonyms Comment Organism
RNase P
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Bacillus subtilis